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Journal of Zhejiang University SCIENCE B 2005 Vol.6 No.1 P.49~52

http://doi.org/10.1631/jzus.2005.B0049


Immunologic changes to autologous transfusion after operational trauma in malignant tumor patients: Neopterin and Interleukin-2


Author(s):  YAN Min, CHEN Gang, FANG Ling-ling, LIU Zi-ming, ZHANG Xiu-lai

Affiliation(s):  Department of Anesthesiology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China

Corresponding email(s):   yanminnina@hotmail.com

Key Words:  Autologous transfusion, Allogeneic transfusion, Serum Neopterin, INF-gamma, Immunologic change


YAN Min, CHEN Gang, FANG Ling-ling, LIU Zi-ming, ZHANG Xiu-lai. Immunologic changes to autologous transfusion after operational trauma in malignant tumor patients: Neopterin and Interleukin-2[J]. Journal of Zhejiang University Science B, 2005, 6(1): 49~52.

@article{title="Immunologic changes to autologous transfusion after operational trauma in malignant tumor patients: Neopterin and Interleukin-2",
author="YAN Min, CHEN Gang, FANG Ling-ling, LIU Zi-ming, ZHANG Xiu-lai",
journal="Journal of Zhejiang University Science B",
volume="6",
number="1",
pages="49~52",
year="2005",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2005.B0049"
}

%0 Journal Article
%T Immunologic changes to autologous transfusion after operational trauma in malignant tumor patients: Neopterin and Interleukin-2
%A YAN Min
%A CHEN Gang
%A FANG Ling-ling
%A LIU Zi-ming
%A ZHANG Xiu-lai
%J Journal of Zhejiang University SCIENCE B
%V 6
%N 1
%P 49~52
%@ 1673-1581
%D 2005
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2005.B0049

TY - JOUR
T1 - Immunologic changes to autologous transfusion after operational trauma in malignant tumor patients: Neopterin and Interleukin-2
A1 - YAN Min
A1 - CHEN Gang
A1 - FANG Ling-ling
A1 - LIU Zi-ming
A1 - ZHANG Xiu-lai
J0 - Journal of Zhejiang University Science B
VL - 6
IS - 1
SP - 49
EP - 52
%@ 1673-1581
Y1 - 2005
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2005.B0049


Abstract: 
Objective: To estimate the impact of autologous transfusion on the status of perioperative immune activation in malignant tumor patients. The serum Neopterin and Interleukin-2 (IL-2) were measured. Methods: Sixty patients undergoing elective radical resection for malignant stomach tumor were enrolled in the prospective study and assigned to the following groups: (1) Group A received autologous transfusion. (2) Group H received allogeneic transfusion. The perioperative course (Before induction of anesthesia, after operation and 5 d after operation) of Neopterin and IL-2 was compared. Results: In group A, serum Neopterin was significantly lower than baseline after operation and IL-2 had no significant changes. In group H, both serum Neopterin and IL-2 were significantly lower than baseline after operation and 5 d after operation. Compared with group A, serum Neopterin was significantly lower than baseline after operation and 5 d after operation and IL-2 was significantly lower than baseline 5 d after operation. Conclusion: autologous transfusion decreased the perioperative immune suppression in malignant stomach tumor patients.

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Reference

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