CLC number: Q42; R99
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
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BINSACK Ralf, ZHENG Ming-lan, ZHANG Zhan-sai, YANG Liu, ZHU Yong-ping. Chronic morphine drinking establishes morphine tolerance, but not addiction in Wistar rats[J]. Journal of Zhejiang University Science B, 2006, 7(11): 892-898.
@article{title="Chronic morphine drinking establishes morphine tolerance, but not addiction in Wistar rats",
author="BINSACK Ralf, ZHENG Ming-lan, ZHANG Zhan-sai, YANG Liu, ZHU Yong-ping",
journal="Journal of Zhejiang University Science B",
volume="7",
number="11",
pages="892-898",
year="2006",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2006.B0892"
}
%0 Journal Article
%T Chronic morphine drinking establishes morphine tolerance, but not addiction in Wistar rats
%A BINSACK Ralf
%A ZHENG Ming-lan
%A ZHANG Zhan-sai
%A YANG Liu
%A ZHU Yong-ping
%J Journal of Zhejiang University SCIENCE B
%V 7
%N 11
%P 892-898
%@ 1673-1581
%D 2006
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2006.B0892
TY - JOUR
T1 - Chronic morphine drinking establishes morphine tolerance, but not addiction in Wistar rats
A1 - BINSACK Ralf
A1 - ZHENG Ming-lan
A1 - ZHANG Zhan-sai
A1 - YANG Liu
A1 - ZHU Yong-ping
J0 - Journal of Zhejiang University Science B
VL - 7
IS - 11
SP - 892
EP - 898
%@ 1673-1581
Y1 - 2006
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2006.B0892
Abstract: Objective: Some animal models apply morphine in the drinking water to generate addiction, but related reports are not free of conflicting results. Accordingly, this study aimed to figure out if chronic consumption of morphine in the drinking water can induce morphine addiction in wistar rats. Methods: For 3 weeks, the animals received a daily morphine dose of 35 mg/kg by offering a calculated volume of sugar water (5% sucrose) with morphine (0.1 mg/ml) to each rat; animals receiving just sugar water served as controls. Immediately after the treatment phase, the tail immersion test was used to check for morphine tolerance, and all animals were then kept on tap water for one week (withdrawal phase). Afterwards, all rats were allowed to choose their drinking source by offering two bottles, containing sugar water without and with morphine, simultaneously for two days (preference phase). Results: While the chronic consumption of morphine led to a reduction in body weight and to morphine tolerance, the morphine-treated wistar rats did not show any preference for the opiate-containing sugar water. Conclusion: Body weight loss and tolerance do not reveal a condition of drug craving, and current animal models should be re-evaluated regarding their potential to establish morphine addicted animals.
[1] Ammon-Treiber, S., Hollt, V., 2005. Morphine-induced changes of gene expression in the brain. Addict. Biol., 10(1):81-89.
[2] Badawy, A.A., Evans, C.M., Evans, M., 1982. Production of tolerance and physical dependence in the rat by simple administration of morphine in drinking water. Br. J. Pharmacol., 75:485-491.
[3] Bailey, C.P., Connor, M., 2005. Opioids: cellular mechanisms of tolerance and physical dependence. Curr. Opin. Pharmacol., 5(1):60-68.
[4] Borg, P.J., Taylor, D.A., 1994. Voluntary oral morphine self-administration in rats: effects of haloperidol or ondansetron. Pharmacol. Biochem. Behav., 47(3):633-646.
[5] Cami, J., Farre, M., 2003. Drug addiction. N. Engl. J. Med., 349(10):975-986.
[6] Contet, C., Kieffer, B.L., Befort, K., 2004. Mu opiod receptor: a gateway to drug addiction. Curr. Opin. Neurobiol., 14(3):370-378.
[7] Dai, S., Hui, S.C.G., Ogle, C.W., 1984. Morphine preference in rats previously morphine dependent. Pharmacol. Res. Commun., 16(5):495-511.
[8] Fábián, G., Tombor, B., Nemeth, I., Kicsi, E.G., Szikszay, M., Horvath, G., Szucs, M., 2003. Upregulation of mu opioid receptors by voluntary morphine administration in drinking water. Acta Biol. Hung., 54(2):157-166.
[9] Gellert, V.F., Holtzman, S.G., 1978. Development and maintenance of morphine tolerance and dependence in the rat by scheduled access to morphine drinking solutions. J. Pharmacol. Exp. Ther., 205:536-546.
[10] Gomaa, A., Hashem, T., Mohamed, M., Ashry, E., 2003. Matricaria chamomilla extract inhibits both development of morphine dependence and expression of abstinence syndrome in rats. J. Pharmacol. Sci., 92(1):50-55.
[11] Hinson, R.E., Poulos, C.X., Thomas, W., Cappell, H., 1986. Pavlovian conditioning and addictive behavior: relapse to oral self-administration of morphine. Behav. Neurosci., 100(3):368-375.
[12] Hui, S.C., Sevilla, E.L., Ogle, C.W., 1996. Prevention by the 5-HT3 receptor antagonist, ondansetron, of morphine-dependence and tolerance in the rat. Br. J. Pharmacol., 118:1044-1050.
[13] Hutchings, D.E., Dow-Edwards, D., 1991. Animal models of opiate, cocaine and cannabis use. Clin. Perinatol., 18:1-22.
[14] Itoh, A., Noda, Y., Mamiya, T., Hasegawa, T., Nabeshima, T., 1998. A therapeutic strategy to prevent morphine dependence and tolerance by coadministration of cAMP-related reagents with morphine. Methods Find. Exp. Clin. Pharmacol., 20(7):619-625.
[15] Jurna, I., Baldauf, J., Zenz, M., 1992. No psychological dependence after oral administration of morphine to rats. Neurosci. Lett., 138(1):77-80.
[16] Koob, G.F., Sanna, P.P., Bloom, F.E., 1998. Neuroscience of addiction. Neuron, 21(3):467-476.
[17] Koob, G.F., Ahmed, S.H., Boutrel, B., Chen, S.A., Kenny, P.J., Markou, A., O'Dell, L.E., Parsons, L.H., Sanna, P.P., 2004. Neurobiological mechanisms in the transition from drug use to drug dependence. Neurosci. Behav. Rev., 27:739-749.
[18] Monteiro, M.G., 2001. A World Health Organization perspective on alcohol and illicit drug use and health. Eur. Addict. Res., 7(3):98-103.
[19] Naidu, P.S., Singh, A., Joshi, D., Kulkani, S.H., 2003. Possible mechanisms of action in quercetin reversal of morphine tolerance and dependence. Addict. Biol., 8(3):327-336.
[20] Nestler, E.J., 2004. Historical review: molecular and cellular mechanisms of opiate and cocaine addiction. Trends Pharmacol. Sci., 25(4):210-218.
[21] Rezvani, A.H., Overstreet, D.H., Perfumi, M., Massi, M., 2003. Plant derivatives in the treatment of alcohol dependency. Pharm. Biochem. Behav., 75(3):593-606.
[22] Silva, M.T., Heyman, G.M., 2001. Chronic morphine consumption decreases wheel running and wheel running-reinforced behavior in rats. Pharmacol. Biochem. Behav., 69(1-2):51-57.
[23] Tiong, G.K., Pierce, T.L., Olley, J.E., 1992. Sub-chronic exposure to opiates in the rat: effects on brain levels of substance P and calcitonin gene-related peptide during dependence and withdrawal. J. Neurosci. Res., 32(4):569-575.
[24] van den Brink, W., van Ree, J.M., 2003. Pharmacological treatments for heroin and cocaine addiction. Eur. Neuropsychopharmacol., 13(6):476-487.
[25] West, J.P., Lysle, D.T., Dykstra, L.A., 1997. Tolerance development to morphine-induced alteration of immune status. Drug Alcohol Depend., 46(3):147-157.
[26] Westerling, D., Perrson, C., Hoglund, P., 1995. Plasma concentrations of morphine, morphine-3-glucuronide, and morphine-6-glucuronide after intravenous and oral administration to healthy volunteers: relationship to nonanalgesic actions. Ther. Drug Monit., 17:287-301.
[27] WHO (World Health Organization), 2002. The World Health Report 2002—Reducing Risk, Promoting Healthy Life. Geneva, WHO.
[28] Wolffgramm, J., Heyne, A., 1995. From controlled drug intake to loss of control: the irreversible development of drug addiction in the rat. Behav. Brain Res., 70(1):77-94.
[29] Yamamoto, T., Mizuguchi, T., 1992. Time-dependent effects of oral morphine on autotomy following brachial nerve section in the rat. Neurosci. Lett., 141(2):166-168.
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