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Received: 2006-03-16

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Journal of Zhejiang University SCIENCE B 2006 Vol.7 No.12 P.998-1005


Effect of glycine site/NMDA receptor antagonist MRZ2/576 on the conditioned place preference and locomotor activity induced by morphine in mice

Author(s):  ZHU Yong-ping, LONG Zai-hao, ZHENG Ming-lan, BINSACK Ralf

Affiliation(s):  Department of Toxicology, School of Medicine, Zhejiang University, Hangzhou 310006, China; more

Corresponding email(s):   zhuyp@zju.edu.cn

Key Words:  Morphine, MRZ2/576, NMDA receptor, Glycine site, Conditioned place

ZHU Yong-ping, LONG Zai-hao, ZHENG Ming-lan, BINSACK Ralf. Effect of glycine site/NMDA receptor antagonist MRZ2/576 on the conditioned place preference and locomotor activity induced by morphine in mice[J]. Journal of Zhejiang University Science B, 2006, 7(12): 998-1005.

@article{title="Effect of glycine site/NMDA receptor antagonist MRZ2/576 on the conditioned place preference and locomotor activity induced by morphine in mice",
author="ZHU Yong-ping, LONG Zai-hao, ZHENG Ming-lan, BINSACK Ralf",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Effect of glycine site/NMDA receptor antagonist MRZ2/576 on the conditioned place preference and locomotor activity induced by morphine in mice
%A ZHU Yong-ping
%A LONG Zai-hao
%A ZHENG Ming-lan
%J Journal of Zhejiang University SCIENCE B
%V 7
%N 12
%P 998-1005
%@ 1673-1581
%D 2006
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2006.B0998

T1 - Effect of glycine site/NMDA receptor antagonist MRZ2/576 on the conditioned place preference and locomotor activity induced by morphine in mice
A1 - ZHU Yong-ping
A1 - LONG Zai-hao
A1 - ZHENG Ming-lan
J0 - Journal of Zhejiang University Science B
VL - 7
IS - 12
SP - 998
EP - 1005
%@ 1673-1581
Y1 - 2006
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2006.B0998

Objective: To study the effect of glycine site/NMDA (N-methyl-D-aspartate) receptor antagonist MRZ2/576 on the conditioned place preference (CPP) and locomotor activity induced by morphine in mice. Methods: Different doses (1.25, 2.5 and 5 mg/kg, i.p.) of MRZ2/576 were used to evaluate the effect of MRZ2/576 on the acquisition and expression of CPP induced by morphine (5 mg/kg) in mice. In addition, we examined the locomotor activity of mice in conditioning and testing phase of CPP paradigm. Results: MRZ2/576 alone could not establish place preference, but a 5 mg/kg dose of MRZ2/576 could block both acquisition and expression of morphine-induced CPP. In testing phase of CPP, there was no statistical difference for locomotor activity between the groups; injection of MRZ2/576 showed a dose-dependent decrease of locomotor activity on both control and morphine-treated mice, especially 5 mg/kg of MRZ2/576 significantly suppressed the locomotor activity of mice. Conclusion: Based on the present results, we assume that MRZ2/576 can antagonize the rewarding effect of morphine, suggesting that this glycine site/NMDA receptor antagonist could be used to treat addictions due to its light side effect profile.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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