Full Text:   <2910>

CLC number: R96

On-line Access: 

Received: 2005-08-12

Revision Accepted: 2005-11-11

Crosschecked: 0000-00-00

Cited: 10

Clicked: 5631

Citations:  Bibtex RefMan EndNote GB/T7714

-   Go to

Article info.
1. Reference List
Open peer comments

Journal of Zhejiang University SCIENCE B 2006 Vol.7 No.3 P.245-250


Effect of matrine and carvedilol on collagen and MMPs activity of hypertrophy myocardium induced by pressure overload

Author(s):  Zhang Ye-Jing, Xiang Mei-Xiang, San Jiang, Cheng Gang, Wang Shi-Sheng

Affiliation(s):  Department of Cardiology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China

Corresponding email(s):   zyjing68@yahoo.com.cn

Key Words:  Matrine, Carvedilol, Myocardial, Hypertrophy fibrosis, MMP-2

Share this article to: More <<< Previous Article|

Zhang Ye-Jing, Xiang Mei-Xiang, San Jiang, Cheng Gang, Wang Shi-Sheng. Effect of matrine and carvedilol on collagen and MMPs activity of hypertrophy myocardium induced by pressure overload[J]. Journal of Zhejiang University Science B, 2006, 7(3): 245-250.

@article{title="Effect of matrine and carvedilol on collagen and MMPs activity of hypertrophy myocardium induced by pressure overload",
author="Zhang Ye-Jing, Xiang Mei-Xiang, San Jiang, Cheng Gang, Wang Shi-Sheng",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Effect of matrine and carvedilol on collagen and MMPs activity of hypertrophy myocardium induced by pressure overload
%A Zhang Ye-Jing
%A Xiang Mei-Xiang
%A San Jiang
%A Cheng Gang
%A Wang Shi-Sheng
%J Journal of Zhejiang University SCIENCE B
%V 7
%N 3
%P 245-250
%@ 1673-1581
%D 2006
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2006.B0245

T1 - Effect of matrine and carvedilol on collagen and MMPs activity of hypertrophy myocardium induced by pressure overload
A1 - Zhang Ye-Jing
A1 - Xiang Mei-Xiang
A1 - San Jiang
A1 - Cheng Gang
A1 - Wang Shi-Sheng
J0 - Journal of Zhejiang University Science B
VL - 7
IS - 3
SP - 245
EP - 250
%@ 1673-1581
Y1 - 2006
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2006.B0245

Objective: To explore the effect and mechanism of matrine (Mt.) on myocardial interstitial fibrosis induced by pressure overload. Methods: Pressure overloaded myocardial hypertrophy was produced by banding of aorta abdominalis in 67 male Sprague-Dawley rats weighing (200±15) g. The rats were assigned into one of the following groups: sham-operation control, operation control, operation group treated with matrine (15 mg/(kg∙d)) and treated with carvedilol (Car.) (3.6 mg/(kg∙d)) group. The rats were given drugs one day after operation. Five weeks after treatment, the left ventricular weight (LVW) was measured and the volume of myocardial cells was detected with Hematoxylin-Eosin (H-E) stain and Masson stain was used to assess the level of fibrosis of the myocardial matrix. myocardial metalloproteinase activity was quantified with zymography, and survival rate was calculated. Results: Survival rate significantly decreased (P<0.05), LVW/BW (body weight), MMP-2 (matrix metalloproteinase-2) activity (P<0.05), size of cardiomyocytes and interstitial fibrosis obviously increased in the operation group compared with sham control group. Mt. and Car. treatment can significantly increase survival rate (P<0.05), decrease LVW/BW (P<0.05) and MMP-2 activity (P<0.05), decrease size of cardiomyocytes and interstitial fibrosis compared with operation group. But there was difference compared with sham group. Conclusion: matrine was shown to be able to prevent cardiac remodelling of hypertrophy cardium induced by pressure overload including myocardial hypertrophy and fibrosis which may be associated with the decrease in MMP-2 activity of heart.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


[1] Ai, J., Gao, H.H., He, S.Z., Wang, L., Luo, D.L., Yang, B.F., 2000. The influence of intracellular [Ca2+]i of ventricular myocytes of guinea pig treated with matrine. Acta Harbin Medical College, 34(4):235-236 (in Chinese).

[2] Cohn, J.N., 1995. Structural basis for heart failure ventricular remodeling and its pharmacological inhibition. Circulation, 91:2504-2507.

[3] Doering, C.W., Jalil, J.E., Janicki, J.S., Pick, R., Aghili, S., Abrahams, C., Weber, K.T., 1988. Collagen network remodelling and diastolic stiffness of the rat left ventricle with pressure overload hypertrophy. Cardiovasc. Res., 22:686-695.

[4] Fung, J.W., Yu, C.M., Yip, G., Chan, S., Yandle, T.G., Richards, A.M., Nicholls, M.G., Sanderson, J.E., 2003. Effect of beta-blockade (carvedilol or metoprolol) on activation of the rennin-angiotensin-aldosterone system and natriuretic peptides in chronic heart failure. Am. J. Cardiol., 92(4):406-410.

[5] Hu, Y.H., Ouyang, J.P., Li, Y.Q., Yang, H.L., Xu, Y., 2004. The influence of cardiac fibroblast cycles and neucleo antigen expression of proliferate cells. Acta Wuhan University: Medical Edition, 3:224-227 (in Chinese).

[6] Leon, A.R., 2003. Cardiac resynchronization therapy devices: patient management and follow-up strategies. Rev. Cardiovasc. Med., 4(suppl 2):S38-S46.

[7] Li, D., Wang, P.Q., Zhang, N.S., 1996. The research development and clinic applications of alkaloid of sophora flavescens ait. Chinese Traditional and Herbal Drug, 27(5):308-311 (in Chinese).

[8] Li, Y., He, L.R., Yang, L.Z., 2000. The matrine intervention of overload of intracellular [Ca2+] of vascular smooth muscle cell induced by Ang II. Acta Traditional Chinese Medical College of Shanghai, 14(1):40-42 (in Chinese).

[9] Lowry, O.H., Rosebrough, N.J. Farr, A.L., Randall, R.J., 1951. Protein measurement with the Folin-Phenol reagents. J. Biol. Chem., 193:265-275.

[10] Luo, X.Y., Zhang, X.M., Gao, W., Wu, Q.F., 2001. The region and mechanism of analgesia treated with matrine. Chinese Traditional and Herbal Drug, 32(1):41-43 (in Chinese).

[11] Song, L., Wang, L.P., He, Z.H., 2001. The relationship of diuresis and pharmacokinetics treated with matrine. Hebei Medicals, 17(8):210-212 (in Chinese).

[12] Tao, S.C., Wan, J.Z., 1992. The pharmacological action of alkaloid of bitter beans. Journal of Chinese Pharmaceutical Science, 27(4):201 (in Chinese).

[13] Tyagi, S.C., Matsubara, L., Weber, K.T., 1993a. Direct extraction and estimation of collagenase(s) activity by zymography in microquantities of rat myocardium and uterus. Clin. Biochem., 26(3):191-198.

[14] Tyagi, S.C., Ratajska, A., Weber, K.T., 1993b. Myocardial matrix and metalloproteinase(s): localization and activation. Mol. Cell. Biochem., 126(1):49-59.

[15] Wang, P.Q., Chen, J.X., Zhou, X.J., 1996. The pharmacokinetics of matrine with rats in vivo. Acta Second Medical College of Shanghai, 16:250-253 (in Chinese).

[16] Wang, C.Q., Huang, D.J., Ding, H.Y., 2000. The change of collagen and matrix metalproteinase(s) activity of pressure overloaded hypertrophy. Basic Medical Sciences and Clinics, 20(2):22-25.

[17] Weber, K.T., 2000. Fibrosis and hypertensive heart disease. Curr. Opin. Cardiol., 15(4):264-272.

[18] Weinberg, E.O., Schoen, F.J., George, D., Kagaya, Y., Douglas, P.S., Litwin, S.E., Schunkert, H., Benedict, C.R., Lorell, B.H., 1994. Angiotensin-converting enzyme inhibition prolongs survival and modifies the transition to heart failure in rats with pressure overload hypertrophy due to ascending aortic stenosis. Circulation, 90(3):1410-1442 (in Chinese).

[19] Xie, H., Wen, H.Y., Gao, Y., Hu, X.J., Zhang, G.Q., 2004. The influence of electrophysiology and mechanics of ventricular myocytes of guinea pig treated with matrine. Bulletin of Chinese Pharmacology, 20(2):192-195 (in Chinese).

[20] Xu, C.Q., Dong, T.L., Du, Z.M., 2004. The comparisons of anti-arrhythmic effect among matrine, berbamine, amiodarone, RP58866. Acta Pharmaceutical Sinica, 39(9):691-694 (in Chinese).

[21] Zhang, D.H., Wang, N.S., Li, X.J., Kong, X.J., Cai, Y.L., 1990a. The anti-arrhythmic effect of matrine. Acta Pharmaco. Sin., 11(3):253-257 (in Chinese).

[22] Zhang, S.S., Li, Z.H., Liu, S.F., 1990b. Relationship between the positive inotropic action of matrine and extracellular calcium. Acta Pharmaceutica Sinica, 25(8):637-639 (in Chinese).

[23] Zhou, Y.F., Ouyang, J.P., Zhou, C.H., Yang, H.L., Xu, Y., Li, K., Wu, K., 2004. The influence and its mechanism of cycles of cardiac fibroblasts treated with matrine. Acta Wuhan University: Medical Edition, 3:220-223 (in Chinese).

Open peer comments: Debate/Discuss/Question/Opinion


Please provide your name, email address and a comment

Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn
Copyright © 2000 - 2024 Journal of Zhejiang University-SCIENCE