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Journal of Zhejiang University SCIENCE B 2006 Vol.7 No.3 P.245~250


Effect of matrine and carvedilol on collagen and MMPs activity of hypertrophy myocardium induced by pressure overload

Author(s):  Zhang Ye-Jing, Xiang Mei-Xiang, San Jiang, Cheng Gang, Wang Shi-Sheng

Affiliation(s):  Department of Cardiology, the Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China

Corresponding email(s):   zyjing68@yahoo.com.cn

Key Words:  Matrine, Carvedilol, Myocardial, Hypertrophy fibrosis, MMP-2

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Zhang Ye-Jing, Xiang Mei-Xiang, San Jiang, Cheng Gang, Wang Shi-Sheng. Effect of matrine and carvedilol on collagen and MMPs activity of hypertrophy myocardium induced by pressure overload[J]. Journal of Zhejiang University Science B, 2006, 7(3): 245~250.

@article{title="Effect of matrine and carvedilol on collagen and MMPs activity of hypertrophy myocardium induced by pressure overload",
author="Zhang Ye-Jing, Xiang Mei-Xiang, San Jiang, Cheng Gang, Wang Shi-Sheng",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Effect of matrine and carvedilol on collagen and MMPs activity of hypertrophy myocardium induced by pressure overload
%A Zhang Ye-Jing
%A Xiang Mei-Xiang
%A San Jiang
%A Cheng Gang
%A Wang Shi-Sheng
%J Journal of Zhejiang University SCIENCE B
%V 7
%N 3
%P 245~250
%@ 1673-1581
%D 2006
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2006.B0245

T1 - Effect of matrine and carvedilol on collagen and MMPs activity of hypertrophy myocardium induced by pressure overload
A1 - Zhang Ye-Jing
A1 - Xiang Mei-Xiang
A1 - San Jiang
A1 - Cheng Gang
A1 - Wang Shi-Sheng
J0 - Journal of Zhejiang University Science B
VL - 7
IS - 3
SP - 245
EP - 250
%@ 1673-1581
Y1 - 2006
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2006.B0245

Objective: To explore the effect and mechanism of matrine (Mt.) on myocardial interstitial fibrosis induced by pressure overload. Methods: Pressure overloaded myocardial hypertrophy was produced by banding of aorta abdominalis in 67 male Sprague-Dawley rats weighing (200±15) g. The rats were assigned into one of the following groups: sham-operation control, operation control, operation group treated with matrine (15 mg/(kg∙d)) and treated with carvedilol (Car.) (3.6 mg/(kg∙d)) group. The rats were given drugs one day after operation. Five weeks after treatment, the left ventricular weight (LVW) was measured and the volume of myocardial cells was detected with Hematoxylin-Eosin (H-E) stain and Masson stain was used to assess the level of fibrosis of the myocardial matrix. myocardial metalloproteinase activity was quantified with zymography, and survival rate was calculated. Results: Survival rate significantly decreased (P<0.05), LVW/BW (body weight), MMP-2 (matrix metalloproteinase-2) activity (P<0.05), size of cardiomyocytes and interstitial fibrosis obviously increased in the operation group compared with sham control group. Mt. and Car. treatment can significantly increase survival rate (P<0.05), decrease LVW/BW (P<0.05) and MMP-2 activity (P<0.05), decrease size of cardiomyocytes and interstitial fibrosis compared with operation group. But there was difference compared with sham group. Conclusion: matrine was shown to be able to prevent cardiac remodelling of hypertrophy cardium induced by pressure overload including myocardial hypertrophy and fibrosis which may be associated with the decrease in MMP-2 activity of heart.

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