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Journal of Zhejiang University SCIENCE B 2007 Vol.8 No.6 P.410~415

10.1631/jzus.2007.B0410


Experiences and benefits of positron emitted tomography-computed tomography (PET-CT) combined with video-assisted thoracoscopic surgery (VATS) in the diagnosis of Stage 1 sarcoidosis


Author(s):  LUH Shi-ping, WU Tzu-chin, WANG Yao-tung, TSAO Thomas Chang-yao, CHEN Jia-yuh

Affiliation(s):  Department of Thoracic Surgery, Chung-Shan Medical University and Hospital, Taichung City 402, Taiwan, China; more

Corresponding email(s):   luh572001@yahoo.com.tw

Key Words:  Sarcoidosis, Video-assisted thoracoscopic surgery (VATS), Positron emitted tomography-computed tomography (PET-CT)


LUH Shi-ping, WU Tzu-chin, WANG Yao-tung, TSAO Thomas Chang-yao, CHEN Jia-yuh. Experiences and benefits of positron emitted tomography-computed tomography (PET-CT) combined with video-assisted thoracoscopic surgery (VATS) in the diagnosis of Stage 1 sarcoidosis[J]. Journal of Zhejiang University Science B, 2007, 8(6): 410~415.

@article{title="Experiences and benefits of positron emitted tomography-computed tomography (PET-CT) combined with video-assisted thoracoscopic surgery (VATS) in the diagnosis of Stage 1 sarcoidosis",
author="LUH Shi-ping, WU Tzu-chin, WANG Yao-tung, TSAO Thomas Chang-yao, CHEN Jia-yuh",
journal="Journal of Zhejiang University Science B",
volume="8",
number="6",
pages="410~415",
year="2007",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2007.B0410"
}

%0 Journal Article
%T Experiences and benefits of positron emitted tomography-computed tomography (PET-CT) combined with video-assisted thoracoscopic surgery (VATS) in the diagnosis of Stage 1 sarcoidosis
%A LUH Shi-ping
%A WU Tzu-chin
%A WANG Yao-tung
%A TSAO Thomas Chang-yao
%A CHEN Jia-yuh
%J Journal of Zhejiang University SCIENCE B
%V 8
%N 6
%P 410~415
%@ 1673-1581
%D 2007
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2007.B0410

TY - JOUR
T1 - Experiences and benefits of positron emitted tomography-computed tomography (PET-CT) combined with video-assisted thoracoscopic surgery (VATS) in the diagnosis of Stage 1 sarcoidosis
A1 - LUH Shi-ping
A1 - WU Tzu-chin
A1 - WANG Yao-tung
A1 - TSAO Thomas Chang-yao
A1 - CHEN Jia-yuh
J0 - Journal of Zhejiang University Science B
VL - 8
IS - 6
SP - 410
EP - 415
%@ 1673-1581
Y1 - 2007
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2007.B0410


Abstract: 
Background: The purpose of this study was to describe our experiences and analyze the benefits of video-assisted thoracoscopic surgery (VATS) combined with positron emitted tomography (PET)-computed tomography (CT) in the diagnosis of patients with early (Stage 1) sarcoidosis. Methods: From 1995 to 2006, seven patients (two males, five females), with ages ranging from 26 to 58 years, were impressed with Stage 1 sarcoidosis (mediastinal or hilar lymph nodes involvements without lung involvement) by histological examination of intrathoracic lymph nodes (LNs) and/or lung parenchyma taken from VATS biopsy. Three of them received PET or PET-CT evaluation. VATS was approached from the right and left side in one and six patients, respectively, according to the locations of their lesions. Results: All the VATS biopsied LNs or lung specimens were adequate for establishing diagnosis. Mediastinal LNs were taken from Groups 3, 4 in four, Group 7 in two, and Groups 5, 6 in one of them. Hilar LNs biopsies were performed in four cases. Lung biopsy was performed in all but two cases. All of them were expressed pathologically or radiologically as Stage 1 sarcoidosis. PET-CT revealed high emission signals over these affected LNs. These patients received oral steroid treatment or follow up only. All of them were followed up from 5 months to 11 years with satisfactory results. Conclusion: VATS biopsy is a minimally invasive, safe and effective procedure. It can be used as a diagnostic alternative of transbronchial lung biopsy (TBLB), and can harvest larger and more areas of specimens than mediastinoscopy for staging patients with sarcoidosis. PET-CT can provide us more accurate information about the characteristics and localization of these lesions before biopsy. VATS combined with PET-CT can provide more accurate and earlier diagnosis of patients with unknown intrathoracic lesions, including the sarcoidosis.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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