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Received: 2019-10-22

Revision Accepted: 2019-12-12

Crosschecked: 2019-12-28

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Yang-yang Fang


Li-yan Dai


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Journal of Zhejiang University SCIENCE A 2020 Vol.21 No.1 P.74-84


NiCo2O4 nanoparticles: an efficient and magnetic catalyst for Knoevenagel condensation

Author(s):  Yang-yang Fang, Xiao-zhong Wang, Ying-qi Chen, Li-yan Dai

Affiliation(s):  Zhejiang Provincial Key Laboratory of Advanced Chemical Engineering Manufacture Technology, College of Chemical and Biological Engineering, Zhejiang University, Hangzhou 310027, China

Corresponding email(s):   wangxiaozhong@zju.edu.cn, dailiyan@zju.edu.cn

Key Words:  NiCo2O4 catalyst, Spinel, Knoevenagel condensation, Heterogeneous catalysis

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Yang-yang Fang, Xiao-zhong Wang, Ying-qi Chen, Li-yan Dai. NiCo2O4 nanoparticles: an efficient and magnetic catalyst for Knoevenagel condensation[J]. Journal of Zhejiang University Science A, 2020, 21(1): 74-84.

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journal="Journal of Zhejiang University Science A",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T NiCo2O4 nanoparticles: an efficient and magnetic catalyst for Knoevenagel condensation
%A Yang-yang Fang
%A Xiao-zhong Wang
%A Ying-qi Chen
%A Li-yan Dai
%J Journal of Zhejiang University SCIENCE A
%V 21
%N 1
%P 74-84
%@ 1673-565X
%D 2020
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.A1900535

T1 - NiCo2O4 nanoparticles: an efficient and magnetic catalyst for Knoevenagel condensation
A1 - Yang-yang Fang
A1 - Xiao-zhong Wang
A1 - Ying-qi Chen
A1 - Li-yan Dai
J0 - Journal of Zhejiang University Science A
VL - 21
IS - 1
SP - 74
EP - 84
%@ 1673-565X
Y1 - 2020
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.A1900535

The knoevenagel condensation reaction has wide applications ranging from the manufacture of basic chemicals to pharmaceutical intermediates. In this study, we developed an efficient and magnetic bimetallic NiCo2O4 nanocatalyst by coprecipitation. When used in the knoevenagel condensation between various benzaldehydes and malononitrile, the catalyst exhibited excellent catalytic performance with 99% conversion and 99% selectivity under mild conditions. It can be easily recovered with a magnet and recycled for 20 runs without significant loss of activity. We expect that the catalyst will find large-scale industrial applications.


目的:脑文格尔缩合反应已被广泛应用于精细化学品、药物、香料和化妆品等领域,是重要的有机合成反应之一. 传统的缩合反应存在催化剂稳定性差、分离难、催化活性低等问题. 本文旨在探讨NiCo2O4的制备方法与结构的关系和催化剂用于脑文格尔缩合反应的条件对性能的影响.
创新点:1. 通过采用不同的煅烧温度,确定合成NiCo2O4尖晶石催化剂的最适温度,以减少NiO的生成; 2. 优化反应条件,使苯甲醛和丙二腈的缩合反应收率达到99%; 3. 获得的NiCo2O4催化剂的稳定性很高,在循环20次后催化性能仍保持不变.
方法:1. 通过X射线单晶衍射和傅里叶红外光谱分析,推断在不同煅烧温度下合成的催化剂的组成,并确定最佳煅烧温度(图2和3); 2. 对NiCo2O4尖晶石催化剂进行透射电镜、二氧化碳/氨气程序升温脱附和氮气吸脱附表征,探究其微观结构与性能之间的关系(图4~8); 3. 通过苯甲醛和丙二腈的脑文格尔缩合反应,验证催化剂的活性.
结论:1. 成功合成出高效的磁性NiCo2O4纳米颗粒; 2. 以脑文格尔缩合反应作为探针反应,发现NiCo2O4具有高催化性能,并且其反应转化率和收率高达99%; 3. 催化剂具有磁性,易于回收; 4. 在循环20次后,反应活性不变,说明催化剂具有高稳定性.

关键词:NiCo2O4催化剂; 尖晶石; 脑文格尔缩合反应; 非均相催化

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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