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Journal of Zhejiang University SCIENCE B 2010 Vol.11 No.11 P.842-847


Pure word deafness associated with extrapontine myelinolysis

Author(s):  Ren-jing Zhu, Zhi-su Lv, Chun-lei Shan, Ming-wei Xu, Ben-yan Luo

Affiliation(s):  Department of Neurology, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310029, China, Department of Neurology, Zhongshan Hospital, Xiamen University, Xiamen 361004, China, Department of Ultrasonography, Children’s Hospital, School of Medicine, Zhejiang University, Hangzhou 310029, China, Laboratory for Higher Brain Function, Institute of Psychology, Chinese Academy of Sciences, Beijing 100101, China, Department of Rehabilitation Medicine, the First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China

Corresponding email(s):   luobenyan@zju.edu.cn

Key Words:  Pure word deafness, Auditory agnosia, Osmotic demyelination syndrome, Extrapontine myelinolysis, Cortical deafness

Ren-jing Zhu, Zhi-su Lv, Chun-lei Shan, Ming-wei Xu, Ben-yan Luo. Pure word deafness associated with extrapontine myelinolysis[J]. Journal of Zhejiang University Science B, 2010, 11(11): 842-847.

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publisher="Zhejiang University Press & Springer",

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%T Pure word deafness associated with extrapontine myelinolysis
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%A Chun-lei Shan
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%A Ben-yan Luo
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%DOI 10.1631/jzus.B1000200

T1 - Pure word deafness associated with extrapontine myelinolysis
A1 - Ren-jing Zhu
A1 - Zhi-su Lv
A1 - Chun-lei Shan
A1 - Ming-wei Xu
A1 - Ben-yan Luo
J0 - Journal of Zhejiang University Science B
VL - 11
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SP - 842
EP - 847
%@ 1673-1581
Y1 - 2010
PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B1000200

extrapontine myelinolysis and pure word deafness are very uncommon disorders. Here, we report a case of a 19-year-old woman who suffered from osmotic demyelination syndrome with coincidence of typical pure word deafness. As a consequence of rapid correction of hyponatremia, the patient demonstrated an initial onset of cortical deafness, and then progressed to generalized auditory agnosia, which eventually developed into confined verbal auditory agnosia (pure word deafness). Bilateral extrapontine myelinolysis was confirmed using brain magnetic resonance imaging. This case suggests that verbal and nonverbal stimuli may involve separate thalamocortical pathways.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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