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Journal of Zhejiang University SCIENCE B 2012 Vol.13 No.1 P.56-82


New developments in small molecular compounds for anti-hepatitis C virus (HCV) therapy

Author(s):  Jing Tong, You-wei Wang, Yuan-an Lu

Affiliation(s):  Department of Public Health Sciences, University of Hawaii, Honolulu, Hawaii 96822, USA, Key Laboratory of Combinatorial Biosynthesis and Drug Discovery, Ministry of Education, Institute of Traditional Chinese Medicine & Natural Products, School of Pharmaceutical Sciences, Wuhan University, Wuhan 430071, China

Corresponding email(s):   ylu@pbrc.hawaii.edu

Key Words:  Hepatitis C virus (HCV), Clinical trial, Small molecular compounds, Review

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Jing Tong, You-wei Wang, Yuan-an Lu. New developments in small molecular compounds for anti-hepatitis C virus (HCV) therapy[J]. Journal of Zhejiang University Science B, 2012, 13(1): 56-82.

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%T New developments in small molecular compounds for anti-hepatitis C virus (HCV) therapy
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%DOI 10.1631/jzus.B1100120

T1 - New developments in small molecular compounds for anti-hepatitis C virus (HCV) therapy
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B1100120

Infection with hepatitis C virus (HCV) affects approximately 170 million people worldwide. However, no vaccine or immunoglobulin is currently available for the prevention of HCV infection. The standard of care (SOC) involving pegylated interferon-α (PEG-IFN α) plus ribavirin (RBV) for 48 weeks results in a sustained virologic response in less than 50% of patients with chronic hepatitis C genotype 1, the most prevalent type of HCV in North America and Europe. Recently, reliable in vitro culture systems have been developed for accelerating antiviral therapy research, and many new specifically targeted antiviral therapies for hepatitis C (STAT-C) and treatment strategies are being evaluated in clinical trials. These new antiviral agents are expected to improve present treatment significantly and may potentially shorten treatment duration. The aim of this review is to summarize the current developments in new anti-HCV drugs.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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2012-01-06 20:22:03

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