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CLC number: R541.4

On-line Access: 2014-03-04

Received: 2013-03-26

Revision Accepted: 2013-08-12

Crosschecked: 2014-02-28

Cited: 12

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Journal of Zhejiang University SCIENCE B 2014 Vol.15 No.3 P.256-263

http://doi.org/10.1631/jzus.B1300088


Association of matrix metalloproteinase-9 C1562T polymorphism and coronary artery disease: a meta-analysis


Author(s):  Xiao Wang1, Lei-zhi Shi1,2

Affiliation(s):  1. Department of Emergency, Zhejiang Hospital, Hangzhou 310013, China; more

Corresponding email(s):   shileizhi@163.com

Key Words:  Coronary artery disease, Matrix metalloproteinase-9, Polymorphism, Meta-analysis


Xiao Wang, Lei-zhi Shi. Association of matrix metalloproteinase-9 C1562T polymorphism and coronary artery disease: a meta-analysis[J]. Journal of Zhejiang University Science B, 2014, 15(3): 256-263.

@article{title="Association of matrix metalloproteinase-9 C1562T polymorphism and coronary artery disease: a meta-analysis",
author="Xiao Wang, Lei-zhi Shi",
journal="Journal of Zhejiang University Science B",
volume="15",
number="3",
pages="256-263",
year="2014",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1300088"
}

%0 Journal Article
%T Association of matrix metalloproteinase-9 C1562T polymorphism and coronary artery disease: a meta-analysis
%A Xiao Wang
%A Lei-zhi Shi
%J Journal of Zhejiang University SCIENCE B
%V 15
%N 3
%P 256-263
%@ 1673-1581
%D 2014
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1300088

TY - JOUR
T1 - Association of matrix metalloproteinase-9 C1562T polymorphism and coronary artery disease: a meta-analysis
A1 - Xiao Wang
A1 - Lei-zhi Shi
J0 - Journal of Zhejiang University Science B
VL - 15
IS - 3
SP - 256
EP - 263
%@ 1673-1581
Y1 - 2014
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1300088


Abstract: 
Objective: Many investigations have studied the associations between matrix metalloproteinase-9 (MMP-9) C1562T polymorphisms and coronary artery disease (CAD). However, the conclusions of these studies were inconsistent. Therefore, this study was aimed at clarifying the association between MMP-9 C1562T polymorphisms and CAD in a large-scale meta-analysis. Methods: The PubMed and Embase databases were retrieved to collect all publications on the association between MMP-9 C1562T polymorphisms and CAD. Then the odd ratios (ORs) and 95% confidence intervals (95% CIs) for C1562T TT+TC versus CC genotype between CAD and the control groups were evaluated. Subgroup analysis was also performed according to different races. The meta-analysis was performed by Stata 10.0. Results: Sixteen case-control studies were included in our meta-analysis, involving 11 032 CAD patients and 4628 non-CAD controls. Compared with C allele carriers, East Asian T allele carriers TT+TC had a significantly higher risk of CAD (OR=1.43; 95% CI: 1.03–1.99; P=0.031); however, there were no significant associations in Western populations (OR=1.06; 95% CI: 0.96–1.18; P=0.240) or West Asians (OR=1.13; 95% CI: 0.75–1.70; P=0.565). When further analyzing the association between C1562T polymorphisms and myocardial infarction (MI, the most serious type of CAD), the risk of TT+TC genotype versus CC genotype for MI was significantly higher for the overall (OR=1.21; 95% CI: 1.04–1.40; P=0.012) and for East Asians (OR=1.58; 95% CI: 1.26–1.97; P=0.000) but not in Western populations (OR=1.12; 95% CI: 0.99–1.26; P=0.078). Conclusions: Our meta-analysis suggested an obvious ethnic difference in the association between MMP-9 C1562T polymorphisms and CAD. MMP-9 C1562T polymorphism was significantly related to CAD in East Asians. However, no significant associations were observed in either West Asians or Western populations.

基质金属蛋白酶-9 C1562T基因多态性与冠心病关系的meta分析

研究目的:探讨基质金属蛋白酶-9(MMP-9)C1562T基因多态性与冠心病之间的关系。
创新要点:通过综合分析,明确了MMP-9 C1562T基因多态性与冠心病的发生存在种族差异性,解决了以往单个研究由于样本量偏少而得出不同结论的弊端。
研究方法:利用meta分析可以扩大样本量的优势,分析了MMP-9 C1562T基因多态性与冠心病间的关系,且研究结论更为可靠。
重要结论:MMP-9 C1562T基因多态性与冠心病的发生存在显著的种族差异性:在东亚人群中,MMP-9 C1562T基因多态性与冠心病的发生密切相关;在西方人群及西亚人群中,MMP-9 C1562T基因多态性与冠心病的发生无显著相关性。

关键词:冠心病;基质金属蛋白酶-9;基因多态性;Meta分析

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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