CLC number: R698.2
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 2015-02-22
Cited: 2
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Kai-fa Tang, Yi-li Zhao, Shang-shu Ding, Qi-fei Wu, Xing-yang Wang, Jia-qi Shi, Fa Sun, Jun-ping Xing. Genetic polymorphisms of CYP2D6*10 and the effectiveness of combined tamoxifen citrate and testosterone undecanoate treatment in infertile men with idiopathic oligozoospermia[J]. Journal of Zhejiang University Science B, 2015, 16(3): 191-197.
@article{title="Genetic polymorphisms of CYP2D6*10 and the effectiveness of combined tamoxifen citrate and testosterone undecanoate treatment in infertile men with idiopathic oligozoospermia",
author="Kai-fa Tang, Yi-li Zhao, Shang-shu Ding, Qi-fei Wu, Xing-yang Wang, Jia-qi Shi, Fa Sun, Jun-ping Xing",
journal="Journal of Zhejiang University Science B",
volume="16",
number="3",
pages="191-197",
year="2015",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1400282"
}
%0 Journal Article
%T Genetic polymorphisms of CYP2D6*10 and the effectiveness of combined tamoxifen citrate and testosterone undecanoate treatment in infertile men with idiopathic oligozoospermia
%A Kai-fa Tang
%A Yi-li Zhao
%A Shang-shu Ding
%A Qi-fei Wu
%A Xing-yang Wang
%A Jia-qi Shi
%A Fa Sun
%A Jun-ping Xing
%J Journal of Zhejiang University SCIENCE B
%V 16
%N 3
%P 191-197
%@ 1673-1581
%D 2015
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1400282
TY - JOUR
T1 - Genetic polymorphisms of CYP2D6*10 and the effectiveness of combined tamoxifen citrate and testosterone undecanoate treatment in infertile men with idiopathic oligozoospermia
A1 - Kai-fa Tang
A1 - Yi-li Zhao
A1 - Shang-shu Ding
A1 - Qi-fei Wu
A1 - Xing-yang Wang
A1 - Jia-qi Shi
A1 - Fa Sun
A1 - Jun-ping Xing
J0 - Journal of Zhejiang University Science B
VL - 16
IS - 3
SP - 191
EP - 197
%@ 1673-1581
Y1 - 2015
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1400282
Abstract: tamoxifen citrate, as the first line of treatment for infertile men with idiopathic oligozoospermia, was proposed by the World Health Organization (WHO), and testosterone undecanoate has shown benefits in semen values. Our objective was to assess the effectiveness of treatment with tamoxifen citrate and testosterone undecanoate in infertile men with idiopathic oligozoospermia, and whether the results would be affected by polymorphisms of CYP2D6*10. A total of 230 infertile men and 147 controls were included in the study. Patients were treated with tamoxifen citrate and testosterone undecanoate. Sex hormone, sperm parameters, and incidence of spontaneous pregnancy were detected. There were no significant differences between the control and patient groups with respect to CYP2D6*10 genotype frequencies (P>0.05). The follicle-stimulation hormone (FSH), luteinizing hormone (LH), and testosterone (T) levels were raised, and sperm concentration and motility were increased at 3 months and became significant at 6 months, and they were higher in the wild-type allele (C/C) than in the heterozygous variant allele (C/T) or homozygous variant allele (T/T) subgroups (P<0.05). In addition, the percentage of normal morphology was raised at 6 months, and represented the highest percentage in the C/C subgroup (P<0.05). The incidence of spontaneous pregnancy in the C/C subgroup was higher than that in the C/T or T/T subgroups (P<0.01). This study showed that the CYP2D6*10 variant genotype demonstrated worse clinical effects in infertile men with idiopathic oligozoospermia.
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