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On-line Access: 2017-04-05

Received: 2016-03-16

Revision Accepted: 2016-07-10

Crosschecked: 2017-03-17

Cited: 1

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Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Bo Yuan

http://orcid.org/0000-0001-9880-4864

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Journal of Zhejiang University SCIENCE B 2017 Vol.18 No.4 P.303-315

10.1631/jzus.B1600118


Rapid prototyping technology and its application in bone tissue engineering


Author(s):  Bo Yuan, Sheng-yuan Zhou, Xiong-sheng Chen

Affiliation(s):  Department of Orthopedic Surgery, Shanghai Changzheng Hospital, the Second Military Medical University, Shanghai 200003, China

Corresponding email(s):   chenxiongsheng@vip.sohu.com

Key Words:  Rapid prototyping, Bone tissue engineering, Scaffolds


Bo Yuan, Sheng-yuan Zhou, Xiong-sheng Chen. Rapid prototyping technology and its application in bone tissue engineering[J]. Journal of Zhejiang University Science B, 2017, 18(4): 303-315.

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doi="10.1631/jzus.B1600118"
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DOI - 10.1631/jzus.B1600118


Abstract: 
Bone defects arising from a variety of reasons cannot be treated effectively without bone tissue reconstruction. Autografts and allografts have been used in clinical application for some time, but they have disadvantages. With the inherent drawback in the precision and reproducibility of conventional scaffold fabrication techniques, the results of bone surgery may not be ideal. This is despite the introduction of bone tissue engineering which provides a powerful approach for bone repair. rapid prototyping technologies have emerged as an alternative and have been widely used in bone tissue engineering, enhancing bone tissue regeneration in terms of mechanical strength, pore geometry, and bioactive factors, and overcoming some of the disadvantages of conventional technologies. This review focuses on the basic principles and characteristics of various fabrication technologies, such as stereolithography, selective laser sintering, and fused deposition modeling, and reviews the application of rapid prototyping techniques to scaffolds for bone tissue engineering. In the near future, the use of scaffolds for bone tissue engineering prepared by rapid prototyping technology might be an effective therapeutic strategy for bone defects.

快速成型技术及其在骨组织工程中的应用

概要:骨缺损的修复是临床工作中亟待解决的难题,寻求完善的骨移植替代物一直是各国学者的研究焦点所在。近年来快速成型技术在骨组织工程领域内的应用逐渐扩大,个体化定制的优势为骨缺损修复提供了新思路。本文对快速成型技术在骨组织工程中的研究进展进行综述,概述了不同快速成型技术的原理和特点,总结其在骨组织工程中的应用现状和发展趋势。
关键词:快速成型技术;骨组织工程;支架

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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