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Bo Yuan


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Journal of Zhejiang University SCIENCE B 2017 Vol.18 No.4 P.303-315


Rapid prototyping technology and its application in bone tissue engineering

Author(s):  Bo Yuan, Sheng-yuan Zhou, Xiong-sheng Chen

Affiliation(s):  Department of Orthopedic Surgery, Shanghai Changzheng Hospital, the Second Military Medical University, Shanghai 200003, China

Corresponding email(s):   chenxiongsheng@vip.sohu.com

Key Words:  Rapid prototyping, Bone tissue engineering, Scaffolds

Bo Yuan, Sheng-yuan Zhou, Xiong-sheng Chen. Rapid prototyping technology and its application in bone tissue engineering[J]. Journal of Zhejiang University Science B, 2017, 18(4): 303-315.

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DOI - 10.1631/jzus.B1600118

Bone defects arising from a variety of reasons cannot be treated effectively without bone tissue reconstruction. Autografts and allografts have been used in clinical application for some time, but they have disadvantages. With the inherent drawback in the precision and reproducibility of conventional scaffold fabrication techniques, the results of bone surgery may not be ideal. This is despite the introduction of bone tissue engineering which provides a powerful approach for bone repair. rapid prototyping technologies have emerged as an alternative and have been widely used in bone tissue engineering, enhancing bone tissue regeneration in terms of mechanical strength, pore geometry, and bioactive factors, and overcoming some of the disadvantages of conventional technologies. This review focuses on the basic principles and characteristics of various fabrication technologies, such as stereolithography, selective laser sintering, and fused deposition modeling, and reviews the application of rapid prototyping techniques to scaffolds for bone tissue engineering. In the near future, the use of scaffolds for bone tissue engineering prepared by rapid prototyping technology might be an effective therapeutic strategy for bone defects.



Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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