Full Text:   <963>

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CLC number: R783.1

On-line Access: 2017-07-05

Received: 2016-12-08

Revision Accepted: 2017-03-22

Crosschecked: 2017-06-16

Cited: 0

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Citations:  Bibtex RefMan EndNote GB/T7714


Xiao-ting Shen


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Journal of Zhejiang University SCIENCE B 2017 Vol.18 No.7 P.615-625


Effects on cytotoxicity and antibacterial properties of the incorporations of silver nanoparticles into the surface coating of dental alloys

Author(s):  Xiao-ting Shen, Yan-zhen Zhang, Fang Xiao, Jing Zhu, Xiao-dong Zheng

Affiliation(s):  Stomatology Hospital Affiliated to Zhejiang University of Medicine, Hangzhou 310006, China; more

Corresponding email(s):   zyz85@hotmail.com, zhujing0721@163.com

Key Words:  Silver nanoparticles (AgNPs), Dental casting, Cytotoxicity, Antibacterial, MC3T3-E1, BMSC

Xiao-ting Shen, Yan-zhen Zhang, Fang Xiao, Jing Zhu, Xiao-dong Zheng. Effects on cytotoxicity and antibacterial properties of the incorporations of silver nanoparticles into the surface coating of dental alloys[J]. Journal of Zhejiang University Science B, 2017, 18(7): 615-625.

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publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Effects on cytotoxicity and antibacterial properties of the incorporations of silver nanoparticles into the surface coating of dental alloys
%A Xiao-ting Shen
%A Yan-zhen Zhang
%A Fang Xiao
%A Jing Zhu
%A Xiao-dong Zheng
%J Journal of Zhejiang University SCIENCE B
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1600555

T1 - Effects on cytotoxicity and antibacterial properties of the incorporations of silver nanoparticles into the surface coating of dental alloys
A1 - Xiao-ting Shen
A1 - Yan-zhen Zhang
A1 - Fang Xiao
A1 - Jing Zhu
A1 - Xiao-dong Zheng
J0 - Journal of Zhejiang University Science B
VL - 18
IS - 7
SP - 615
EP - 625
%@ 1673-1581
Y1 - 2017
PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B1600555

The aim of this study was to research the changes in cytotoxicity and antibacterial properties after silver nanoparticles (AgNPs) were incorporated into the surface coating of dental alloys. AgNPs were attached to cobalt chromium alloys and pure titanium using a hydrothermal method, according to the reaction: AgNO3+NaBH4→ Ag+1/2H2+1/2B2H6+NaNO3. A 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay was used to evaluate the cytotoxicity of the alloys when in contact with osteogenic precursor cells (MC3T3-E1) from mice and mesenchymal stem cells (BMSC) from rats. The antibacterial properties of dental alloys incorporating three different concentrations (10, 4, and 2 μmol/L) of AgNPs were tested on Staphylococcus aureus (SA) and Streptococcus mutans (MS). High cytotoxicity values were observed for all dental alloys that contained 0% of AgNPs (the control groups). The incorporation of AgNPs reduced cytotoxicity values. No significant difference was observed for antibacterial performance when comparing dental alloys containing AgNPs to the respective control groups. The results demonstrated that the cobalt chromium alloys and pure titanium all had cytotoxicity to MC3T3-E1 and BMSC and that the incorporation of AgNPs could reduce this cytotoxicity. The concentrations of AgNPs adopted in this study were found to have no antibacterial action against SA or MS.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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