CLC number: R285.5
On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 2020-08-17
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Mee Lee Looi, Alwyn Khai Howe Wong, Shelly Anne Gnapragasan, Anis Zafirah Japri, Aiysvariyah Rajedadram, Kar Yong Pin. Anti-migratory effects of Piper betle leaf aqueous extract on cancer cells and its microtubule targeting properties[J]. Journal of Zhejiang University Science B, 2020, 21(9): 745-748.
@article{title="Anti-migratory effects of Piper betle leaf aqueous extract on cancer cells and its microtubule targeting properties",
author="Mee Lee Looi, Alwyn Khai Howe Wong, Shelly Anne Gnapragasan, Anis Zafirah Japri, Aiysvariyah Rajedadram, Kar Yong Pin",
journal="Journal of Zhejiang University Science B",
volume="21",
number="9",
pages="745-748",
year="2020",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2000278"
}
%0 Journal Article
%T Anti-migratory effects of Piper betle leaf aqueous extract on cancer cells and its microtubule targeting properties
%A Mee Lee Looi
%A Alwyn Khai Howe Wong
%A Shelly Anne Gnapragasan
%A Anis Zafirah Japri
%A Aiysvariyah Rajedadram
%A Kar Yong Pin
%J Journal of Zhejiang University SCIENCE B
%V 21
%N 9
%P 745-748
%@ 1673-1581
%D 2020
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2000278
TY - JOUR
T1 - Anti-migratory effects of Piper betle leaf aqueous extract on cancer cells and its microtubule targeting properties
A1 - Mee Lee Looi
A1 - Alwyn Khai Howe Wong
A1 - Shelly Anne Gnapragasan
A1 - Anis Zafirah Japri
A1 - Aiysvariyah Rajedadram
A1 - Kar Yong Pin
J0 - Journal of Zhejiang University Science B
VL - 21
IS - 9
SP - 745
EP - 748
%@ 1673-1581
Y1 - 2020
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2000278
Abstract: Piper betle (PB), also known as “betel” in Malay language, is a tropical Asian vine. PB leaves are commonly chewed by Asians along with betel quid. It contains phenols such as eugenol and hydroxychavicol along with chlorophyll, β-carotene, and vitamin C (Salehi et al., 2019). Extracts from PB leaves have various medicinal properties including anticancer, antioxidant, anti-inflammatory, and antibacterial effects (Salehi et al., 2019). Previous research has shown that PB induces cell cycle arrest at late S or G2/M phase and causes apoptosis at higher doses (Wu et al., 2014; Guha Majumdar and Subramanian, 2019). A combination of PB leaf extract has also been shown to enhance the cytotoxicity of the anticancer drug, 5-fluorouracil (5-FU), in cancer cells (Ng et al., 2014).
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