Full Text:   <2713>

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CLC number: R779.65

On-line Access: 2024-08-27

Received: 2023-10-17

Revision Accepted: 2024-05-08

Crosschecked: 2018-02-07

Cited: 0

Clicked: 4830

Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Yu-feng Yao

https://orcid.org/0000-0003-1494-9711

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Journal of Zhejiang University SCIENCE B 2018 Vol.19 No.3 P.218-226

http://doi.org/10.1631/jzus.B1700095


Assessments of tear meniscus height, tear film thickness, and corneal epithelial thickness after deep anterior lamellar keratoplasty


Author(s):  Wen-jia Xie, Ye-sheng Xu, Xia Zhang, Yu-feng Yao

Affiliation(s):  Department of Ophthalmology, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou 310016, China

Corresponding email(s):   yaoyf@zju.edu.cn

Key Words:  Tear meniscus height, Corneal epithelial thickness, Tear film, Deep anterior lamellar keratoplasty (DALK), High-definition optical coherence tomography (HD-OCT), Keratoconus


Wen-jia Xie, Ye-sheng Xu, Xia Zhang, Yu-feng Yao. Assessments of tear meniscus height, tear film thickness, and corneal epithelial thickness after deep anterior lamellar keratoplasty[J]. Journal of Zhejiang University Science B, 2018, 19(3): 218-226.

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author="Wen-jia Xie, Ye-sheng Xu, Xia Zhang, Yu-feng Yao",
journal="Journal of Zhejiang University Science B",
volume="19",
number="3",
pages="218-226",
year="2018",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1700095"
}

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%T Assessments of tear meniscus height, tear film thickness, and corneal epithelial thickness after deep anterior lamellar keratoplasty
%A Wen-jia Xie
%A Ye-sheng Xu
%A Xia Zhang
%A Yu-feng Yao
%J Journal of Zhejiang University SCIENCE B
%V 19
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1700095

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T1 - Assessments of tear meniscus height, tear film thickness, and corneal epithelial thickness after deep anterior lamellar keratoplasty
A1 - Wen-jia Xie
A1 - Ye-sheng Xu
A1 - Xia Zhang
A1 - Yu-feng Yao
J0 - Journal of Zhejiang University Science B
VL - 19
IS - 3
SP - 218
EP - 226
%@ 1673-1581
Y1 - 2018
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1700095


Abstract: 
Objective: To assess the lower tear meniscus height (LTMH), central tear film thickness (CTFT), and central corneal epithelial thickness (CCET) after deep anterior lamellar keratoplasty (DALK). Methods: This was a retrospective cross-sectional study of 20 patients who had DALK in one eye over a three-month period. LTMH, CTFT, and CCET of the operated eyes and the unoperated fellow eyes were measured using high-definition optical coherence tomography (HD-OCT). Correlations between three OCT assessments and age, time following surgery, graft size, bed size, and the number of residual sutures were analyzed. Results: Compared to patients with keratoconus, patients with other corneal conditions had significantly higher CCET in the fellow eye (P=0.024). For all patients, CCET in the operated eye was significantly negatively correlated with the number of residual sutures (R=−0.579, P=0.008), and was significantly positively correlated with time following surgery (R=0.636, P=0.003). In the fellow eye, a significant positive correlation was found between age and CCET (R=0.551, P=0.012), and a significant negative correlation between age and CTFT (R=−0.491, P=0.028). LTMH was found to be significantly correlated between operated and fellow eyes (R=0.554, P=0.011). There was no significant correlation between LTMH and age, bed/graft size, time following surgery, or residual sutures (all possible correlations, P>0.05). Conclusions: Patients with keratoconus tend to have a thinner central corneal epithelium. Corneal epithelium keeps regenerating over time after DALK. DALK did not induce a significant change in tear volume compared with the fellow eye. Postoperative tear function might depend on an individual’s general condition, rather than on age, gender, bed/graft size, time following surgery, or residual sutures.

前部深板层角膜移植术后泪新月高度、泪膜厚度及角膜上皮厚度的评估

目的:评估前部深板层角膜移植(DALK)术后的下泪新月高度(LTMH)、中央泪膜厚度(CTFT)及中央角膜上皮厚度(CCET).
创新点:首次利用高清光学相干断层扫描成像技术(HD-OCT)定量测量DALK术后的CCET、CTFT和LTMH,并发现各个参数之间及与其他临床数据的相关性.
方法:回顾性横断面分析20例单眼DALK术后3月以上的患者.使用HD-OCT定量分析并比较术眼和对侧未手术眼的LTMH、CTFT和CCET.对各个OCT参数之间及与年龄、术后时间、植片直径、植床直径和残余缝线数量进行相关性分析.
结论:本研究显示,圆锥角膜患者的中央角膜上皮倾向变薄;DALK术后角膜上皮随着时间推移而持续再生;与对侧未手术眼相比,DALK并不引起显著的泪液量变化.因此,术后的泪液功能可能取决于患者的整体状况而非年龄、性别、植片/植床直径、术后时间或残余缝线.

关键词:泪新月高度;角膜上皮厚度;泪膜;前部深板层角膜移植(DALK);高清光学相干断层扫描成像技术(HD-OCT);圆锥角膜

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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