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CLC number: R587.1

On-line Access: 2020-11-05

Received: 2020-04-30

Revision Accepted: 2020-08-05

Crosschecked: 2020-10-15

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Xia-hong Lin


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Journal of Zhejiang University SCIENCE B 2020 Vol.21 No.11 P.911-920


Diagnostic value of optic disc retinal nerve fiber layer thickness for diabetic peripheral neuropathy

Author(s):  Xiao-hong Wu, Jing-wen Fang, Yin-qiong Huang, Xue-feng Bai, Yong Zhuang, Xiao-yu Chen, Xia-hong Lin

Affiliation(s):  Department of Endocrinology, the Second Affiliated Hospital of Fujian Medical University, Quanzhou 362000, China; more

Corresponding email(s):   linxiahongdr@fjmu.edu.cn

Key Words:  Type 2 diabetes, Peripheral neuropathy, Retinal nerve fiber layer thickness, Optical coherence tomography, Diagnosis

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Xiao-hong Wu, Jing-wen Fang, Yin-qiong Huang, Xue-feng Bai, Yong Zhuang, Xiao-yu Chen, Xia-hong Lin. Diagnostic value of optic disc retinal nerve fiber layer thickness for diabetic peripheral neuropathy[J]. Journal of Zhejiang University Science B, 2020, 21(11): 911-920.

@article{title="Diagnostic value of optic disc retinal nerve fiber layer thickness for diabetic peripheral neuropathy",
author="Xiao-hong Wu, Jing-wen Fang, Yin-qiong Huang, Xue-feng Bai, Yong Zhuang, Xiao-yu Chen, Xia-hong Lin",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Diagnostic value of optic disc retinal nerve fiber layer thickness for diabetic peripheral neuropathy
%A Xiao-hong Wu
%A Jing-wen Fang
%A Yin-qiong Huang
%A Xue-feng Bai
%A Yong Zhuang
%A Xiao-yu Chen
%A Xia-hong Lin
%J Journal of Zhejiang University SCIENCE B
%V 21
%N 11
%P 911-920
%@ 1673-1581
%D 2020
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2000225

T1 - Diagnostic value of optic disc retinal nerve fiber layer thickness for diabetic peripheral neuropathy
A1 - Xiao-hong Wu
A1 - Jing-wen Fang
A1 - Yin-qiong Huang
A1 - Xue-feng Bai
A1 - Yong Zhuang
A1 - Xiao-yu Chen
A1 - Xia-hong Lin
J0 - Journal of Zhejiang University Science B
VL - 21
IS - 11
SP - 911
EP - 920
%@ 1673-1581
Y1 - 2020
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2000225

Objective: To investigate the value of optic disc retinal nerve fiber layer (RNFL) thickness in the diagnosis of diabetic peripheral neuropathy (DPN). Methods: Ninety patients with type 2 diabetes, including 60 patients without DPN (NDPN group) and 30 patients with DPN (DPN group), and 30 healthy participants (normal group) were enrolled. optical coherence tomography (OCT) was used to measure the four quadrants and the overall average RNFL thickness of the optic disc. The receiver operator characteristic curve was drawn and the area under the curve (AUC) was calculated to evaluate the diagnostic value of RNFL thickness in the optic disc area for DPN. Results: The RNFL thickness of the DPN group was thinner than those of the normal and NDPN groups in the overall average ((101.07± 12.40) µm vs. (111.07±6.99) µm and (109.25±6.90) µm), superior quadrant ((123.00±19.04) µm vs. (138.93±14.16) µm and (134.47±14.34) µm), and inferior quadrant ((129.37±17.50) µm vs. (143.60±12.22) µm and (144.48±14.10) µm), and the differences were statistically significant. The diagnostic efficiencies of the overall average, superior quadrant, and inferior quadrant RNFL thicknesses, and a combined index of superior and inferior quadrant RNFL thicknesses were similar, and the AUCs were 0.739 (95% confidence interval (CI) 0.635–0.826), 0.683 (95% CI 0.576–0.778), 0.755 (95% CI 0.652–0.840), and 0.773 (95% CI 0.672–0.854), respectively. The diagnostic sensitivity of RNFL thickness in the superior quadrant reached 93.33%. Conclusions: The thickness of the RNFL in the optic disc can be used as a diagnostic method for DPN.




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[39]List of electronic supplementary materials

[40]Table S1 Complete nerve electromyography data of the DPN and NDPN groups

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