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CLC number: R373

On-line Access: 2018-05-05

Received: 2017-08-02

Revision Accepted: 2017-10-01

Crosschecked: 2018-04-18

Cited: 0

Clicked: 2584

Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Cheng-long Xiong

https://orcid.org/0000-0003-4750-3572

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Journal of Zhejiang University SCIENCE B 2018 Vol.19 No.5 P.409-414

http://doi.org/10.1631/jzus.B1700374


Avian influenza viruses (AIVs) H9N2 are in the course of reassorting into novel AIVs


Author(s):  Hui-ping Chang, Li Peng, Liang Chen, Lu-fang Jiang, Zhi-jie Zhang, Cheng-long Xiong, Gen-ming Zhao, Yue Chen, Qing-wu Jiang

Affiliation(s):  Department of Life Sciences, Henan Institute of Education, Zhengzhou 450000, China; more

Corresponding email(s):   chenglongxiong@vip.sina.com

Key Words:  Avian Influenza Virus, H9N2, H10N8, H7N9, China, Co-originating


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Hui-ping Chang, Li Peng, Liang Chen, Lu-fang Jiang, Zhi-jie Zhang, Cheng-long Xiong, Gen-ming Zhao, Yue Chen, Qing-wu Jiang. Avian influenza viruses (AIVs) H9N2 are in the course of reassorting into novel AIVs[J]. Journal of Zhejiang University Science B, 2018, 19(5): 409-414.

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Abstract: 
In 2013, two episodes of influenza emerged in china and caused worldwide concern. A new h7N9 avian Influenza Virus (AIV) first appeared in china on February 19, 2013. By August 31, 2013, the virus had spread to ten provinces and two metropolitan cities. Of 134 patients with h7N9 influenza, 45 died. From then on, epidemics emerged sporadically in china and resulted in several victims. On November 30, 2013, a 73-year-old woman presented with an influenza-like illness. She developed multiple organ failure and died 9 d after the onset of disease. A novel reassortant AIV, h10N8, was isolated from a tracheal aspirate specimen that was obtained from the patient 7 d after onset. This case was the first human case of influenza A subtype h10N8. On 4 February, 2014, another death due to h10N8 avian influenza was reported in Jiangxi Province, china.

H9N2,行进在新亚型流感病毒的途中

目的:分析H9N2禽流感病毒通过基因重配形成H7N9和H10N8人间禽流感病毒的进程,探讨作为供体的禽流感病毒H9N2在当前中国的主要分布及其内部6个基因节段的进化关系.
创新点:人间禽流感病毒H7N9和H10N8共起源于H9N2禽流感病毒早已成为共识,但共起源的时间节点、作为供体的禽流感病毒H9N2在当前中国的分布及其内部6个基因节段的进化关系鲜有论及.2014年,H5N6禽流感被多次报道造成人类感染.研究表明,H5N6禽流感具有复杂的重配来源,H9N2正是其一,加之H7N9第五波流行的严峻形势,亟需明确H9N2禽流感病毒通过基因重配形成新亚型的能力以及它在我国的当前主要分布.
方法:从流感病毒公共数据库下载基因序列,评估查找适当的碱基替代模型,通过进化树查看与H7N9、H10N8及H5N6具有高度相似性的H9N2病毒的分布地区以及它们在内部6个基因节段上的进化关系,同时通过碱基替代速率的计算追溯最近共同祖先(tMRCA)及其分歧时间.
结论:人间禽流感病毒H7N9与H10N8均在2012年之前形成,短期内通过碱基替代与基因重配形成了两种可感染人类的禽流感病毒,证实了H9N2通过重配形成新亚型的高效性.作为重配供体的H9N2至今仍广布于华东、华南及东南亚.其内部基因节段的重配复杂,发生在亚型内部的重配以及通过重配形成新的病毒亚型的风险都很高,需在禽畜中加强流感病毒的流行动态监测,特别是那些一向被忽视的编码内部蛋白的基因组节段.

关键词:禽流感病毒;H9N2;H10N8;H7N9;中国;共起源

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[21]Extensive reading

[22]Part of details about this research had been presented as a public preprint archive on bioRxiv, which was entitled Notorious Novel Avian Influenza Viruses H10N8 and H7N9 in China in 2013 Co-originated from H9N2. It can be extensively read at the website: http://www.biorxiv.org/content/early/2014/04/21/004390.article-metrics

[23]List of electronic supplementary materials

[24]Data S1 Materials and methods

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