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CLC number: R373

On-line Access: 2018-05-05

Received: 2017-08-02

Revision Accepted: 2017-10-01

Crosschecked: 2018-04-18

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Citations:  Bibtex RefMan EndNote GB/T7714


Cheng-long Xiong


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Journal of Zhejiang University SCIENCE B 2018 Vol.19 No.5 P.409-414


Avian influenza viruses (AIVs) H9N2 are in the course of reassorting into novel AIVs

Author(s):  Hui-ping Chang, Li Peng, Liang Chen, Lu-fang Jiang, Zhi-jie Zhang, Cheng-long Xiong, Gen-ming Zhao, Yue Chen, Qing-wu Jiang

Affiliation(s):  Department of Life Sciences, Henan Institute of Education, Zhengzhou 450000, China; more

Corresponding email(s):   chenglongxiong@vip.sina.com

Key Words:  Avian Influenza Virus, H9N2, H10N8, H7N9, China, Co-originating

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Hui-ping Chang, Li Peng, Liang Chen, Lu-fang Jiang, Zhi-jie Zhang, Cheng-long Xiong, Gen-ming Zhao, Yue Chen, Qing-wu Jiang. Avian influenza viruses (AIVs) H9N2 are in the course of reassorting into novel AIVs[J]. Journal of Zhejiang University Science B, 2018, 19(5): 409-414.

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In 2013, two episodes of influenza emerged in china and caused worldwide concern. A new h7N9 avian Influenza Virus (AIV) first appeared in china on February 19, 2013. By August 31, 2013, the virus had spread to ten provinces and two metropolitan cities. Of 134 patients with h7N9 influenza, 45 died. From then on, epidemics emerged sporadically in china and resulted in several victims. On November 30, 2013, a 73-year-old woman presented with an influenza-like illness. She developed multiple organ failure and died 9 d after the onset of disease. A novel reassortant AIV, h10N8, was isolated from a tracheal aspirate specimen that was obtained from the patient 7 d after onset. This case was the first human case of influenza A subtype h10N8. On 4 February, 2014, another death due to h10N8 avian influenza was reported in Jiangxi Province, china.




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[1]Bi Y, Chen Q, Wang Q, et al., 2016. Genesis, evolution and prevalence of H5N6 avian influenza viruses in China. Cell Host Microbe, 20(6):810-821.

[2]Chen H, Yuan H, Gao R, et al., 2014. Clinical and epidemiological characteristics of a fatal case of avian influenza A H10N8 virus infection: a descriptive study. Lancet, 383(9918):714-721.

[3]Chen L, Lin X, Tian J, et al., 2017. Diversity, evolution and population dynamics of avian influenza viruses circulating in the live poultry markets in China. Virology, 505: 33-41.

[4]Chen Y, Liang W, Yang S, et al., 2013. Human infections with the emerging avian influenza a H7N9 virus from wet market poultry: clinical analysis and characterization of viral genome. Lancet, 381(9881):1916-1925.

[5]Cheng X, Liu J, He J, et al., 2002. Virological and serological surveys for H9N2 subtype of influenza a virus in chickens and men in Shenzhen city. Chin J Exp Clin Virol, 16(4):319-321 (in Chinese).

[6]Cui L, Liu D, Shi W, et al., 2014. Dynamic reassortments and genetic heterogeneity of the human-infecting influenza a (H7N9) virus. Nat Commun, 5:3142.

[7]Dong G, Xu C, Wang C, et al., 2011. Reassortant H9N2 influenza viruses containing H5N1-like PB1 genes isolated from black-billed magpies in southern China. PLoS ONE, 6(9):e25808.

[8]Du Y, Chen M, Yang J, et al., 2017. Molecular evolution and emergence of H5N6 avian influenza virus in central China. J Virol, 91(12):e00143-17.

[9]Gu M, Liu WB, Cao JP, et al., 2010. Genome sequencing and genetic analysis of a natural reassortant H5N1 subtype avian influenza virus possessing H9N2 internal genes. Chin J Virol, 26(4):298-304 (in Chinese).

[10]Gu M, Xu L, Wang X, et al., 2017. Current situation of H9N2 subtype avian influenza in China. Vet Res, 48(1):49.

[11]Iuliano AD, Jang Y, Jones J, et al., 2017. Increase in human infections with avian influenza A (H7N9) virus during the fifth epidemic—China, October 2016–February 2017. Morb Mortal Wkly Rep, 66(9):254-255.

[12]Jiang W, Liu S, Hou G, et al., 2012. Chinese and global distribution of H9 subtype avian influenza viruses. PLoS ONE, 7(12):e52671.

[13]Jiao P, Cui J, Song Y, et al., 2016. New reassortant H5N6 highly pathogenic avian influenza viruses in Southern China, 2014. Front Microbiol, 7:754.

[14]Kang Y, Liu L, Feng M, et al., 2017. Highly pathogenic H5N6 influenza a viruses recovered from wild birds in Guangdong, southern China, 2014–2015. Sci Rep, 7:44410.

[15]Li Q, Zhou L, Zhou M, et al., 2014. Epidemiology of human infections with avian influenza A (H7N9) virus in China. New Engl J Med, 370(6):520-532.

[16]Liu M, Li X, Yuan H, et al., 2015. Genetic diversity of avian influenza A (H10N8) virus in live poultry markets and its association with human infections in China. Sci Rep, 5: 7632. https://dx.doi.org/10.1038/srep07632

[17]Padidam M, Sawyer S, Fauquet C, 1999. Possible emergence of new geminiviruses by frequent recombination. Virol, 265(2):218-225.

[18]Tang Q, Shao M, Xu L, 2017. China is closely monitoring an increase in infection with avian influenza A (H7N9) virus. Biosci Trends, 11(1):122-124.

[19]WHO (World Health Organization), 2017. Influenza at the human-animal interface summary and assessment, 21 April to 16 May 2017. http://www.who.int/influenza/human_animal_interface/Influenza_Summary_IRA_HA_interface_ 05_16_2017.pdf?ua=1 [Accessed on May 25, 2017].

[20]Zhang Z, Li R, Jiang L, et al., 2016. The complexity of human infected AIV H5N6 isolated from China. BMC Infect Dis, 16:600.

[21]Extensive reading

[22]Part of details about this research had been presented as a public preprint archive on bioRxiv, which was entitled Notorious Novel Avian Influenza Viruses H10N8 and H7N9 in China in 2013 Co-originated from H9N2. It can be extensively read at the website: http://www.biorxiv.org/content/early/2014/04/21/004390.article-metrics

[23]List of electronic supplementary materials

[24]Data S1 Materials and methods

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