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On-line Access: 2019-04-01

Received: 2018-10-09

Revision Accepted: 2019-02-12

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Journal of Zhejiang University SCIENCE B 2019 Vol.20 No.4 P.291-299


Advances in low-frequency ultrasound combined with microbubbles in targeted tumor therapy

Author(s):  Li-Ying Wang, shu-Sen Zheng

Affiliation(s):  Department of Ultrasound, Shaoxing Second Hospital, Shaoxing 312000, China; more

Corresponding email(s):   drwang88@qq.com

Key Words:  Low-frequency ultrasound, Microbubble, Gene, Drug, Cell death

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Li-Ying Wang, shu-Sen Zheng. Advances in low-frequency ultrasound combined with microbubbles in targeted tumor therapy[J]. Journal of Zhejiang University Science B, 2019, 20(4): 291-299.

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The development of low-frequency ultrasound imaging technology and the improvement of ultrasound contrast agent production technology mean that they play an increasingly important role in tumor therapy. The interaction between ultrasound and microbubbles and their biological effects can transfer and release microbubbles carrying genes and drugs to target tissues, mediate the apoptosis of tumor cells, and block the embolization of tumor microvasculature. With the optimization of ultrasound parameters, the development of targeted microbubbles, and the emergence of various composite probes with both diagnostic and therapeutic functions, low-frequency ultrasound combined with microbubble contrast agents will bring new hope for clinical tumor treatment.



Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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