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On-line Access: 2019-05-15

Received: 2019-03-28

Revision Accepted: 2019-04-11

Crosschecked: 2019-04-27

Cited: 0

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Citations:  Bibtex RefMan EndNote GB/T7714


Li-sheng Zhuo


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Journal of Zhejiang University SCIENCE B 2019 Vol.20 No.5 P.428-436


Roles of hyaluronan in cardiovascular and nervous system disorders

Author(s):  Hong-yan Ding, Ya-nan Xie, Qiang Dong, Koji Kimata, Yoshihiro Nishida, Naoki Ishiguro, Li-sheng Zhuo

Affiliation(s):  Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, China; more

Corresponding email(s):   zhuols@gmail.com

Key Words:  Hyaluronic acid, Extracellular matrix, Cardiovascular vessel, Heart, Brain

Hong-yan Ding, Ya-nan Xie, Qiang Dong, Koji Kimata, Yoshihiro Nishida, Naoki Ishiguro, Li-sheng Zhuo. Roles of hyaluronan in cardiovascular and nervous system disorders[J]. Journal of Zhejiang University Science B, 2019, 20(5): 428-436.

@article{title="Roles of hyaluronan in cardiovascular and nervous system disorders",
author="Hong-yan Ding, Ya-nan Xie, Qiang Dong, Koji Kimata, Yoshihiro Nishida, Naoki Ishiguro, Li-sheng Zhuo",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Roles of hyaluronan in cardiovascular and nervous system disorders
%A Hong-yan Ding
%A Ya-nan Xie
%A Qiang Dong
%A Koji Kimata
%A Yoshihiro Nishida
%A Naoki Ishiguro
%A Li-sheng Zhuo
%J Journal of Zhejiang University SCIENCE B
%V 20
%N 5
%P 428-436
%@ 1673-1581
%D 2019
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1900155

T1 - Roles of hyaluronan in cardiovascular and nervous system disorders
A1 - Hong-yan Ding
A1 - Ya-nan Xie
A1 - Qiang Dong
A1 - Koji Kimata
A1 - Yoshihiro Nishida
A1 - Naoki Ishiguro
A1 - Li-sheng Zhuo
J0 - Journal of Zhejiang University Science B
VL - 20
IS - 5
SP - 428
EP - 436
%@ 1673-1581
Y1 - 2019
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1900155

Hyaluronan is a widely occurring extracellular matrix molecule, which is not only a supporting structural component, but also an active regulator of cellular functions. The chemophysical and biological properties of hyaluronan are greatly affected by its molecular size and several hyaluronan-binding proteins, making hyaluronan a fascinating molecule with great functional diversity. This review summarizes our current understanding of the roles of hyaluronan in cardiovascular and nervous system disorders, such as atherosclerosis, myocardial infarction, and stroke, with the aim to provide a foundation for future research and clinical trials.


关键词:透明质酸; 细胞外基质;心血管;心脏;脑

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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