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Journal of Zhejiang University SCIENCE B 1998 Vol.-1 No.-1 P.

http://doi.org/10.1631/jzus.B2000555


Serum macrophage migration inhibitory factor as a potential biomarker to evaluate therapeutic response in patients with allergic asthma: an exploratory study


Author(s):  Huiyuan ZHU, Shaochun YAN, Jingshuo WU, Zhong ZHANG, Xiaolin LI, Zheng LIU, Xing MA, Lina ZHOU, Lin ZHANG, Mingming FENG, Yiwei GENG, Aixin ZHANG, Sabina JANCIAUSKIENE, Aiguo XU

Affiliation(s):  Department of Pulmonary and Critical Care Medicine, Zhengzhou Second People’ more

Corresponding email(s):   aiguoxu@zzu.edu.cn

Key Words:  macrophage migration inhibitory factor, allergic asthma, eosinophilic inflammation, fractional exhaled nitric oxide, IgE


Huiyuan ZHU, Shaochun YAN, Jingshuo WU, Zhong ZHANG, Xiaolin LI, Zheng LIU, Xing MA, Lina ZHOU, Lin ZHANG, Mingming FENG, Yiwei GENG, Aixin ZHANG, Sabina JANCIAUSKIENE, Aiguo XU. Serum macrophage migration inhibitory factor as a potential biomarker to evaluate therapeutic response in patients with allergic asthma: an exploratory study[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .

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author="Huiyuan ZHU, Shaochun YAN, Jingshuo WU, Zhong ZHANG, Xiaolin LI, Zheng LIU, Xing MA, Lina ZHOU, Lin ZHANG, Mingming FENG, Yiwei GENG, Aixin ZHANG, Sabina JANCIAUSKIENE, Aiguo XU",
journal="Journal of Zhejiang University Science B",
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year="1998",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2000555"
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%0 Journal Article
%T Serum macrophage migration inhibitory factor as a potential biomarker to evaluate therapeutic response in patients with allergic asthma: an exploratory study
%A Huiyuan ZHU
%A Shaochun YAN
%A Jingshuo WU
%A Zhong ZHANG
%A Xiaolin LI
%A Zheng LIU
%A Xing MA
%A Lina ZHOU
%A Lin ZHANG
%A Mingming FENG
%A Yiwei GENG
%A Aixin ZHANG
%A Sabina JANCIAUSKIENE
%A Aiguo XU
%J Journal of Zhejiang University SCIENCE B
%V -1
%N -1
%P
%@ 1673-1581
%D 1998
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2000555

TY - JOUR
T1 - Serum macrophage migration inhibitory factor as a potential biomarker to evaluate therapeutic response in patients with allergic asthma: an exploratory study
A1 - Huiyuan ZHU
A1 - Shaochun YAN
A1 - Jingshuo WU
A1 - Zhong ZHANG
A1 - Xiaolin LI
A1 - Zheng LIU
A1 - Xing MA
A1 - Lina ZHOU
A1 - Lin ZHANG
A1 - Mingming FENG
A1 - Yiwei GENG
A1 - Aixin ZHANG
A1 - Sabina JANCIAUSKIENE
A1 - Aiguo XU
J0 - Journal of Zhejiang University Science B
VL - -1
IS - -1
SP -
EP -
%@ 1673-1581
Y1 - 1998
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2000555


Abstract: 
Background: Previous studies have shown that macrophage migration inhibitory factor (MIF) is involved in the pathogenesis of asthma. This study aimed to investigate whether serum MIF reflects a therapeutic response in allergic asthma. Methods: We enrolled 30 asthmatic patients with mild-to-moderate exacerbations and 20 healthy controls, analyzing the parameter levels of serum MIF, serum total igE (tigE), peripheral blood eosinophil percentage (EOS%), and fractional exhaled nitric oxide (FeNO). Lung function indices were used to identify disease severity and therapeutic response. Results: Our results showed that all measured parameters in patients before treatment were at higher levels than those of controls. After one week of treatment, most parameter levels decreased significantly except for serum tigE. Furthermore, we found that serum MIF positively correlated with EOS% as well as FeNO, but negatively correlated with lung function indices. Receiver operator characteristic (ROC) curve analysis indicated that among the parameters, serum MIF exhibited a higher capacity to evaluate therapeutic response. The area under the curve (AUC) of MIF was 0.931, with a sensitivity of 0.967 and specificity of 0.8. Conclusion: Our results suggest that serum MIF may serve as a potential biomarker for evaluating therapeutic response in allergic asthma with mild-to-moderate exacerbations.

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