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Lisha ZHOU


Yingying ZHU


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Journal of Zhejiang University SCIENCE B 2021 Vol.22 No.11 P.959-965


NEDD8-conjugating enzyme E2 UBE2F confers radiation resistance by protecting lung cancer cells from apoptosis

Author(s):  Lisha ZHOU, Changsheng DONG, Zhuoming XU, Xinran WANG, Luyi ZHANG, Siyuan CHEN, Jiahao CHEN, Yingying ZHU

Affiliation(s):  Department of Basic Medicine, Medical College, Taizhou University, Taizhou 318000, China; more

Corresponding email(s):   lishazhou@tzc.edu.cn, zhuyingying1988@tzc.edu.cn

Key Words:  UBE2F, oxidative stress, Radiosensitization, Apoptosis, Lung cancer

Lisha ZHOU, Changsheng DONG, Zhuoming XU, Xinran WANG, Luyi ZHANG, Siyuan CHEN, Jiahao CHEN, Yingying ZHU. NEDD8-conjugating enzyme E2 UBE2F confers radiation resistance by protecting lung cancer cells from apoptosis[J]. Journal of Zhejiang University Science B, 2021, 22(11): 959-965.

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author="Lisha ZHOU, Changsheng DONG, Zhuoming XU, Xinran WANG, Luyi ZHANG, Siyuan CHEN, Jiahao CHEN, Yingying ZHU",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

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%T NEDD8-conjugating enzyme E2 UBE2F confers radiation resistance by protecting lung cancer cells from apoptosis
%A Lisha ZHOU
%A Changsheng DONG
%A Zhuoming XU
%A Xinran WANG
%A Siyuan CHEN
%A Jiahao CHEN
%A Yingying ZHU
%J Journal of Zhejiang University SCIENCE B
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%D 2021
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2100170

T1 - NEDD8-conjugating enzyme E2 UBE2F confers radiation resistance by protecting lung cancer cells from apoptosis
A1 - Lisha ZHOU
A1 - Changsheng DONG
A1 - Zhuoming XU
A1 - Xinran WANG
A1 - Luyi ZHANG
A1 - Siyuan CHEN
A1 - Jiahao CHEN
A1 - Yingying ZHU
J0 - Journal of Zhejiang University Science B
VL - 22
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SP - 959
EP - 965
%@ 1673-1581
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B2100170

lung cancer, which is exacerbated by environmental pollution and tobacco use, has become the most common cause of cancer-related deaths worldwide, with a five-year overall survival rate of only 19% (Siegel et al., 2020; Yang et al., 2020; Yu and Li, 2020). Nearly 85% of lung cancers are non-small cell lung cancers, of which lung adenocarcinoma is the most common subtype accounting for 50% of non-small cell lung cancer cases. At present, radiotherapy is the primary therapeutic modality for lung cancer at different stages, with significant prolongation of survival time (Hirsch et al., 2017; Bai et al., 2019; Shi et al., 2020). Irradiation can generate reactive oxygen species (ROS) through the radiolysis reaction of water and oxygen, cause DNA damage and oxidative stress, and subsequently result in cancer cell death (Kim et al., 2019). Nevertheless, radioresistance seriously hinders the success of treatment for lung cancer, owing to local recurrence and distant metastasis (Huang et al., 2021). Compared with small cell lung cancer, non-small cell lung cancer shows more tolerance to radiotherapy. Therefore, it is of great importance to decipher key mechanisms of radioresistance and identify effective molecular radiosensitizers to improve patient survival.




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