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On-line Access: 2022-06-16

Received: 2022-03-03

Revision Accepted: 2022-05-22

Crosschecked: 2022-09-16

Cited: 0

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Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Denis KUZNETSOV

https://orcid.org/0000-0003-0884-848X

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Journal of Zhejiang University SCIENCE B 2022 Vol.23 No.9 P.784-790

http://doi.org/10.1631/jzus.B2200107


Use of folic acid nanosensors with excellent photostability for hybrid imaging


Author(s):  Denis KUZNETSOV, Sergey DEZHUROV, Dmitri KRYLSKY, Valery NOVIKOV, Valery NESCHISLIAEV, Anastasiia KUZNETSOVA

Affiliation(s):  GN. Gabrichevsky Scientific and Research Institute of Epidemiology and Microbiology, Moscow 125212, Russia; more

Corresponding email(s):   denis.pfa@gmail.com

Key Words:  Stomach cancer, Hybrid imaging, Nanosensors, Photostability, Folic acid


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Denis KUZNETSOV, Sergey DEZHUROV, Dmitri KRYLSKY, Valery NOVIKOV, Valery NESCHISLIAEV, Anastasiia KUZNETSOVA. Use of folic acid nanosensors with excellent photostability for hybrid imaging[J]. Journal of Zhejiang University Science B, 2022, 23(9): 784-790.

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journal="Journal of Zhejiang University Science B",
volume="23",
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pages="784-790",
year="2022",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2200107"
}

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A1 - Valery NESCHISLIAEV
A1 - Anastasiia KUZNETSOVA
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Abstract: 
Sentinel lymph node (SLN) mapping and tumor-boundary delineation play a key role in cancer surgery, as they have great potential to reduce surgical intervention and increase relapse-free survival rates of patients. The autofluorescence imaging (AFI) method can improve the efficiency of tumor delineation and optimize the scope of surgical intervention, but there are still no fluorescent drugs that can be used with such a method to form a hybrid imaging technique. Another problem is bleaching when fluorescent dyes are conjugated with folic acid. This study reports, for the first time, nanosensors with excellent photostability and compatibility with endoscopes for AFI, which makes simultaneous hybrid imaging possible. After functionalization of the quantum dot (QD) surfaces, we found that they bound effectively to MCF-7 cancer cells. The diagnostic value of simultaneous hybrid imaging using common AFI equipment in delineating tumor boundaries and mapping SLN can reduce the cost of diagnosis and increase its reliability.

一种光稳定性优异的叶酸纳米传感器在混合成像中的应用

概要:前哨淋巴结绘图和肿瘤边界的确定能有效减少手术干预及提高患者的无复发生存率,在癌症手术中发挥重要作用。自体荧光成像(AFI)技术可提高肿瘤检测率且优化手术干预范围,可惜目前尚无可用于混合成像的荧光标记药物,而且荧光染料与叶酸结合时易出现光漂白现象。本研究首次报道了一种可用于同步混合成像的叶酸纳米传感器,其光稳定性优异且与AFI内窥镜兼容。经过量子点表面功能化处理后,该纳米传感器能够与MCF-7癌细胞有效结合,从而可使用普通AFI设备进行同步混合成像诊断,进行前哨淋巴结绘图和确定肿瘤边界,这不仅降低诊断的成本,也提高了诊断的可靠性。

关键词:胃癌;混合成像;纳米传感器;光稳定性;叶酸

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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