Full Text:
<356>
CLC number:
On-line Access: 2023-01-16
Received: 2022-11-29
Revision Accepted: 2023-01-03
Crosschecked: 0000-00-00
Cited: 0
Clicked: 326
Scutellarin prevents acute alcohol-induced liver injury via inhibiting oxidative stress by regulating the Nrf2/HO-1 pathway and inhibiting inflammation by regulating the AKT, P38 MAPK/NF-κB pathway
| |||||||||||||
Xiao ZHANG, Zhicheng DONG, Hui FAN, Qiankun YANG, Guili YU, Enzhuang PAN, Nana HE, Xueqing LI, Panpan ZHAO, Mian FU, Jingquan DONG. Scutellarin prevents acute alcohol-induced liver injury via inhibiting oxidative stress by regulating the Nrf2/HO-1 pathway and inhibiting inflammation by regulating the AKT, P38 MAPK/NF-κB pathway[J]. Journal of Zhejiang University Science B, 1998, -1(-1): .
@article{title="Scutellarin prevents acute alcohol-induced liver injury via inhibiting oxidative stress by regulating the Nrf2/HO-1 pathway and inhibiting inflammation by regulating the AKT, P38 MAPK/NF-κB pathway",
author="Xiao ZHANG, Zhicheng DONG, Hui FAN, Qiankun YANG, Guili YU, Enzhuang PAN, Nana HE, Xueqing LI, Panpan ZHAO, Mian FU, Jingquan DONG",
journal="Journal of Zhejiang University Science B",
volume="-1",
number="-1",
pages="",
year="1998",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2200612"
}
%0 Journal Article
%T Scutellarin prevents acute alcohol-induced liver injury via inhibiting oxidative stress by regulating the Nrf2/HO-1 pathway and inhibiting inflammation by regulating the AKT, P38 MAPK/NF-κB pathway
%A Xiao ZHANG
%A Zhicheng DONG
%A Hui FAN
%A Qiankun YANG
%A Guili YU
%A Enzhuang PAN
%A Nana HE
%A Xueqing LI
%A Panpan ZHAO
%A Mian FU
%A Jingquan DONG
%J Journal of Zhejiang University SCIENCE B
%V -1
%N -1
%P
%@ 1673-1581
%D 1998
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2200612
TY - JOUR
T1 - Scutellarin prevents acute alcohol-induced liver injury via inhibiting oxidative stress by regulating the Nrf2/HO-1 pathway and inhibiting inflammation by regulating the AKT, P38 MAPK/NF-κB pathway
A1 - Xiao ZHANG
A1 - Zhicheng DONG
A1 - Hui FAN
A1 - Qiankun YANG
A1 - Guili YU
A1 - Enzhuang PAN
A1 - Nana HE
A1 - Xueqing LI
A1 - Panpan ZHAO
A1 - Mian FU
A1 - Jingquan DONG
J0 - Journal of Zhejiang University Science B
VL - -1
IS - -1
SP -
EP -
%@ 1673-1581
Y1 - 1998
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2200612
Abstract: alcoholic liver disease (ALD) is the most frequent liver disease worldwide, resulting in severe harm to personal health and posing a serious burden to public health. Based on the reported antioxidant and anti-inflammatory capacities of scutellarin (SCU), this study investigated its protective role in BALB/c mice with acute alcoholic liver injury after oral administration (10, 25 and 50 mg/kg). The results indicate that SCU could lessen serum ALT and AST levels and improve the histopathological changes in acute alcoholic liver; it reduced alcohol-induced MDA content and increased GSH-Px, CAT and SOD activities. Furthermore, SCU restrained the increase in TNF-α, IL-6, and IL-1β mRNA expression levels, iNOS activity, and NLRP3 inflammasome activation. Mechanistically, SCU suppressed CYP2E1 upregulation triggered by alcohol, increased the expression of oxidative stress-related Nrf2 and HO-1 pathways, and suppressed the inflammation-related degradation of IκBα as well as activation of NF-κB by mediating the AKT and P38 MAPK pathways. These findings demonstrate that SCU protects against acute alcoholic liver injury via inhibiting oxidative stress by regulating the Nrf2/HO-1 pathway and suppressing inflammation by regulating the AKT, P38 MAPK/NF-κB pathway.
Open peer comments: Debate/Discuss/Question/Opinion
<1>