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On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
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Duo LV, Xishao XIE, Qinyun YANG, Zhimin CHEN, Guangjun LIU, Wenhan PENG, Rending WANG, Hongfeng HUANG, Jianghua CHEN, Jianyong WU. Clinical characteristics and outcomes of hospitalized kidney transplant recipients with COVID-19 infection in China during the Omicron wave: a single-center cohort study[J]. Journal of Zhejiang University Science B, 2024, 25(6): 529-540.
@article{title="Clinical characteristics and outcomes of hospitalized kidney transplant recipients with COVID-19 infection in China during the Omicron wave: a single-center cohort study",
author="Duo LV, Xishao XIE, Qinyun YANG, Zhimin CHEN, Guangjun LIU, Wenhan PENG, Rending WANG, Hongfeng HUANG, Jianghua CHEN, Jianyong WU",
journal="Journal of Zhejiang University Science B",
volume="25",
number="6",
pages="529-540",
year="2024",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2300538"
}
%0 Journal Article
%T Clinical characteristics and outcomes of hospitalized kidney transplant recipients with COVID-19 infection in China during the Omicron wave: a single-center cohort study
%A Duo LV
%A Xishao XIE
%A Qinyun YANG
%A Zhimin CHEN
%A Guangjun LIU
%A Wenhan PENG
%A Rending WANG
%A Hongfeng HUANG
%A Jianghua CHEN
%A Jianyong WU
%J Journal of Zhejiang University SCIENCE B
%V 25
%N 6
%P 529-540
%@ 1673-1581
%D 2024
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2300538
TY - JOUR
T1 - Clinical characteristics and outcomes of hospitalized kidney transplant recipients with COVID-19 infection in China during the Omicron wave: a single-center cohort study
A1 - Duo LV
A1 - Xishao XIE
A1 - Qinyun YANG
A1 - Zhimin CHEN
A1 - Guangjun LIU
A1 - Wenhan PENG
A1 - Rending WANG
A1 - Hongfeng HUANG
A1 - Jianghua CHEN
A1 - Jianyong WU
J0 - Journal of Zhejiang University Science B
VL - 25
IS - 6
SP - 529
EP - 540
%@ 1673-1581
Y1 - 2024
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2300538
Abstract: BackgroundFollowing the short-term outbreak of coronavirus disease 2019 (COVID-19) in December 2022 in China, clinical data on kidney transplant recipients (KTRs) with COVID-19 are lacking.
MethodsWe conducted a single-center retrospective study to describe the clinical features, complications, and mortality rates of hospitalized KTRs infected with COVID-19 between Dec. 16, 2022 and Jan. 31, 2023. The patients were followed up until Mar. 31, 2023.
ResultsA total of 324 KTRs with COVID-19 were included. The median age was 49 years. The median time between the onset of symptoms and admission was 13 d. Molnupiravir, azvudine, and nirmatrelvir/ritonavir were administered to 67 (20.7%), 11 (3.4%), and 148 (45.7%) patients, respectively. Twenty-nine (9.0%) patients were treated with more than one antiviral agent. Forty-eight (14.8%) patients were treated with tocilizumab and 53 (16.4%) patients received baricitinib therapy. The acute kidney injury (AKI) occurred in 81 (25.0%) patients and 39 (12.0%) patients were admitted to intensive care units. Fungal infections were observed in 55 (17.0%) patients. Fifty (15.4%) patients lost their graft. The 28-d mortality rate of patients was 9.0% and 42 (13.0%) patients died by the end of follow-up. Multivariate Cox regression analysis identified that cerebrovascular disease, AKI incidence, interleukin (IL)-6 level of >6.8 pg/mL, daily dose of corticosteroids of >50 mg, and fungal infection were all associated with an increased risk of death for hospitalized patients.
ConclusionsOur findings demonstrate that hospitalized KTRs with COVID-19 are at high risk of mortality. The administration of immunomodulators or the late application of antiviral drugs does not improve patient survival, while higher doses of corticosteroids may increase the death risk.
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