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Journal of Zhejiang University SCIENCE B 2024 Vol.25 No.11 P.941-955

http://doi.org/10.1631/jzus.B2300743


Prefrontal cortical circuits in social behaviors: an overview


Author(s):  Wei CAO, Huiyi LI, Jianhong LUO

Affiliation(s):  Institute of Brain Science and Department of Physiology, School of Basic Medical Sciences, Hangzhou Normal University, Hangzhou311121, China; more

Corresponding email(s):   luojianhong@zju.edu.cn

Key Words:  Prefrontal cortex (PFC), Social behavior, Autism spectrum disorder (ASD), Schizophrenia (SCZ), Parvalbumin-positive interneuron, N-Methyl-D-aspartate receptor (NMDAR)


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Wei CAO, Huiyi LI, Jianhong LUO. Prefrontal cortical circuits in social behaviors: an overview[J]. Journal of Zhejiang University Science B, 2024, 25(11): 941-955.

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Abstract: 
social behaviors are fundamental and intricate functions in both humans and animals, governed by the interplay of social cognition and emotions. A noteworthy feature of several neuropsychiatric disorders, including autism spectrum disorder (ASD) and schizophrenia (SCZ), is a pronounced deficit in social functioning. Despite a burgeoning body of research on social behaviors, the precise neural circuit mechanisms underpinning these phenomena remain to be elucidated. In this paper, we review the pivotal role of the prefrontal cortex (PFC) in modulating social behaviors, as well as its functional alteration in social disorders in ASD or SCZ. We posit that PFC dysfunction may represent a critical hub in the pathogenesis of psychiatric disorders characterized by shared social deficits. Furthermore, we delve into the intricate connectivity of the medial PFC (mPFC) with other cortical areas and subcortical brain regions in rodents, which exerts a profound influence on social behaviors. Notably, a substantial body of evidence underscores the role of N-methyl-D-aspartate receptors (NMDARs) and the proper functioning of parvalbumin-positive interneurons within the mPFC for social regulation. Our overarching goal is to furnish a comprehensive understanding of these intricate circuits and thereby contribute to the enhancement of both research endeavors and clinical practices concerning social behavior deficits.

前额叶皮层环路与社交行为概述

曹蔚1,3,4,李慧怡1,3,罗建红2,5,6
1杭州师范大学基础医学院,脑科学研究所,中国杭州市,311121
2浙江大学医学院附属医院精神卫生中心,杭州市第七人民医院,中国杭州市,310013
3杭州师范大学基础医学院, 浙江省医学表观遗传学重点实验室,中国杭州市,311121
4杭州师范大学,婴幼儿发展与托育实验室,中国杭州市,311121
5浙大城市学院医学院,浙江省神经损伤修复新靶点及药物研究重点实验室,中国杭州市,310015
6浙江大学,国家卫生健康委员会医学神经生物学重点实验室,中国杭州市,310058
摘要:社交是人类和动物基本而复杂的行为,受社会认知和情感相互作用的调控。社交障碍发病率高,同样也是自闭症谱系障碍(ASD)和精神分裂症(SCZ)等神经精神疾病的显著临床特征。尽管有关社交行为神经的基础研究不断增多,但其精确的神经环路机制仍然有待阐明。本文回顾了前额叶皮层(PFC)在调节社交行为中的关键作用及其在社交障碍中的功能改变。大量研究提示:PFC功能障碍可能是以社交缺陷为共同特征的精神疾病发病机制的关键病理节点。此外,本文深入梳理了啮齿类动物内侧PFC(mPFC)与其他皮层区域和皮层下大脑区域的复杂连接,以及这些连接在社交行为调控中的作用。值得注意的是,大量证据强调了mPFC的N-甲基-D-天冬氨酸(NMDA)受体以及小清蛋白阳性中间神经元的正常功能在调控社交行为中的作用。因此,深入解析社交相关的神经环路及其功能,将有助于揭示社交障碍的神经病理机制并指导临床转化研究。

关键词:前额叶皮层;社交行为;自闭症谱系障碍;精神分裂症;小清蛋白阳性中间神经元;N-甲基-D-天冬氨酸(NMDA)受体

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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