JZUS - Journal of Zhejiang University SCIENCE

Journal of Zhejiang University SCIENCE B

Accepted manuscript available online (unedited version)

Inverse associations of outdoor activity and vitamin D intake with the risk of Parkinsons disease

Author(s): Dan Zhu¹, Gui-you Liu², Zheng Lv³, Shi-rong Wen⁴, Sheng Bi⁴, Wei-zhi Wang¹
Affiliation(s): 1. Department of Neurology, the Second Affiliated Hospital, Harbin Medical University, Harbin 150086, China;2. Genome Analysis Laboratory, Tianjin Institute of Industrial Biotechnology, Chinese Academy of Sciences, Tianjin 300308, China;3. Department of Rehabilitation, the First Affiliated Hospital, Harbin Medical University, Harbin 150001, China;4. Department of Neurology, the First Affiliated Hospital, Harbin Medical University, Harbin 150001, China
Corresponding email(s): dwangwz@163.com
Key Words: Outdoor activity, Vitamin D intake, Parkinsons disease

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Dan Zhu, Gui-you Liu, Zheng Lv, Shi-rong Wen, Sheng Bi, Wei-zhi Wang. Inverse associations of outdoor activity and vitamin D intake with the risk of Parkinson’s disease[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B1400005

@article{title="Inverse associations of outdoor activity and vitamin D intake with the risk of Parkinson’s disease",
author="Dan Zhu, Gui-you Liu, Zheng Lv, Shi-rong Wen, Sheng Bi, Wei-zhi Wang",
journal="Journal of Zhejiang University Science B",
year="in press",
publisher="Zhejiang University Press & Springer",
doi="https://doi.org/10.1631/jzus.B1400005"
}

%0 Journal Article
%T Inverse associations of outdoor activity and vitamin D intake with the risk of Parkinson’s disease
%A Dan Zhu
%A Gui-you Liu
%A Zheng Lv
%A Shi-rong Wen
%A Sheng Bi
%A Wei-zhi Wang
%J Journal of Zhejiang University SCIENCE B
%P 923-927
%@ 1673-1581
%D in press
%I Zhejiang University Press & Springer
doi="https://doi.org/10.1631/jzus.B1400005"

TY - JOUR
T1 - Inverse associations of outdoor activity and vitamin D intake with the risk of Parkinson’s disease
A1 - Dan Zhu
A1 - Gui-you Liu
A1 - Zheng Lv
A1 - Shi-rong Wen
A1 - Sheng Bi
A1 - Wei-zhi Wang
J0 - Journal of Zhejiang University Science B
SP - 923
EP - 927
%@ 1673-1581
Y1 - in press
PB - Zhejiang University Press & Springer
ER -
doi="https://doi.org/10.1631/jzus.B1400005"

Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: Early studies had suggested that vitamin D intake was inversely associated with neurodegenerative diseases, such as Alzheimer’s disease and multiple sclerosis. However, the associations of vitamin D intake and outdoor activities with Parkinson’s disease (PD) are still unclear, so this study is to evaluate these relationships from a case-control study in elderly Chinese. The study population involved 209 cases with new onsets of PD and 210 controls without neurodegenerative diseases. The data on dietary vitamin D and outdoor activities were collected using a food-frequency questionnaire and self-report questionnaire. Multivariable logistic regressions were used to examine the associations between dietary outdoor activities, vitamin D intake and PD. Adjustment was made for sex, age, smoking, alcohol use, education, and body mass index (BMI). Adjusted odds ratios (ORs) for PD in quartiles for outdoor physical activity were 1 (reference), 0.739 (0.413, 1.321), 0.501 (0.282, 0.891), and 0.437 (0.241, 0.795), respectively (P=0.002 for trend). Adjusted ORs for PD in quartiles for total vitamin D intake were 1 (reference), 0.647 (0.357, 1.170), 0.571 (0.318, 1.022), and 0.538 (0.301, 0.960), respectively (P=0.011 for trend). Our study suggested that outdoor activity and total vitamin D intake were inversely associated with PD, and outdoor activity seems to be more significantly associated with decreased risk for PD.

户外活动和维生素D的摄入量与帕金森病的风险呈负相关

研究目的：评估户外活动、维生素D的摄入与帕金森病（PD）风险关系。
研究方法：收集209例新发PD病例和210名无神经退行性疾病对照人群，进行食物频率问卷调查，计算膳食维生素D摄入量并记录自我报告的问卷调查户外活动情况。利用多变量Logistic回归研究膳食维生素D摄入及户外活动与PD的相关性，并校正性别、年龄、吸烟、饮酒、教育程度和身体质量指数（BMI）变量。按户外活动时间从少到多四分位分组，校正后的比值比（OR）（95%可信区间（CI））值分别为1（参考）、0.739（0.413，1.321）、0.501（0.282，0.891）和0.437（0.241，0.795），趋势P=0.002；按维生素D摄入量从少到多四分位分组，校正后的OR值分别为1（参考）、0.647（0.357，1.170）、0.571（0.318，1.022）和0.538（0.301，0.960），趋势P=0.011。
重要结论：表明户外活动和总的维生素D摄入量与PD呈负相关；户外活动可更显著下降PD的风险相关。
户外活动；维生素D摄入量；帕金森氏病

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References

[1] Abrantes,A.M, Friedman,J.H, Brown,R.A, 2012, Physical activity and neuropsychiatric symptoms of Parkinson disease J Geriatr Psychiatry Neurol, 25(3):138-145.

[2] 2007, Nutrition recommendations and interventions for diabetes: a position statement of the American diabetes association Diabetes Care, 30(Suppl. 1):S48-S65.

[3] Anderson,C, Checkoway,H, Franklin,G.M, 1999, Dietary factors in Parkinsons disease: the role of food groups and specific foods Mov Disord, 14(1):21-27.

[4] Annweiler,C, Llewellyn,D.J, Beauchet,O, 2013, Low serum vitamin D concentrations in Alzheimers disease: a systematic review and meta-analysis J Alzheimers Dis, 33(3):659-674.

[5] Buell,J.S, Dawson-Hughes,B, 2008, Vitamin D and neurocognitive dysfunction: preventing Decline? Mol Aspects Med, 29(6):415-422.

[6] Gao,X, Chen,H, Fung,T.T, 2007, Prospective study of dietary pattern and risk of Parkinson disease Am J Clin Nutr, 86(5):1486-1494.

[7] Holick,M.F, 2007, Vitamin D deficiency N Engl J Med, 357(3):266-281.

[8] Jiang,W, Ju,C, Jiang,H, 2014, Dairy foods intake and risk of Parkinsons disease: a dose-response meta-analysis of prospective cohort studies Eur J Epidemiol, 29(9):613-619.

[9] Kenborg,L, Lassen,C.F, Ritz,B, 2011, Outdoor work and risk for Parkinsons disease: a population-based case-control study Occup Environ Med, 68(4):273-278.

[10] Knekt,P, Kilkkinen,A, Rissanen,H, 2010, Serum vitamin D and the risk of Parkinson disease Arch Neurol, 67(7):808-811.

[11] Lees,A.J, Hardy,J, Revesz,T, 2009, Parkinsons disease Lancet, 373(9680):2055-2066.

[12] Li,Y, Wang,C, Zhu,K, 2010, Effects of multivitamin and mineral supplementation on adiposity, energy expenditure and lipid profiles in obese Chinese women Int J Obes, 34(6):1070-1077.

[13] Liu,P, Feng,T, Wang,Y.J, 2011, Clinical heterogeneity in patients with early-stage Parkinsons disease: a cluster analysis J Zhejiang Univ-Sci B (Biomed & Biotechnol), 12(9):694-703.

[14] Marcinowska-Suchowierska,E, Walicka,M, Talalaj,M, 2010, Vitamin D supplementation in adults-guidelines Endokrynol Pol, 61(6):723-729.

[15] Miyake,Y, Tanaka,K, Fukushima,W, 2011, Lack of association of dairy food, calcium, and vitamin D intake with the risk of Parkinsons disease: a case-control study in Japan Parkinsonism Relat Disord, 17(2):112-116.

[16] Park,M, Ross,G.W, Petrovitch,H, 2005, Consumption of milk and calcium in midlife and the future risk of Parkinson disease Neurology, 64(6):1047-1051.

[17] Ross,G.W, Abbott,R.D, Petrovitch,H, 2000, Association of coffee and caffeine intake with the risk of Parkinson disease JAMA, 283(20):2674-2679.

[18] Sehanovic,A, Dostovic,Z, Smajlovic,D, 2011, Quality of life in patients suffering from Parkinsons disease and multiple sclerosis Med Arch, 65(5):291-294.

[19] Speelman,A.D, van de Warrenburg,B.P, van Nimwegen,M, 2011, How might physical activity benefit patients with Parkinson disease? Nat Rev Neurol, 7(9):528-534.

[20] van den Bos,F, Speelman,A.D, van Nimwegen,M, 2013, Bone mineral density and vitamin D status in Parkinsons disease patients J Neurol, 260(3):754-760.

[21] Voelker,R, 2006, Parkinson disease guidelines aid diagnosis, management JAMA, 295(18):2126-2128.

[22] Xu,Q, Park,Y, Huang,X, 2010, Physical activities and future risk of Parkinson disease Neurology, 75(4):341-348.

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户外活动和维生素D的摄入量与帕金森病的风险呈负相关

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References