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CLC number: R741

On-line Access: 2014-10-08

Received: 2014-01-03

Revision Accepted: 2014-06-11

Crosschecked: 2014-07-25

Cited: 3

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Citations:  Bibtex RefMan EndNote GB/T7714

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Journal of Zhejiang University SCIENCE B 2014 Vol.15 No.10 P.923-927


Inverse associations of outdoor activity and vitamin D intake with the risk of Parkinson’s disease

Author(s):  Dan Zhu1, Gui-you Liu2, Zheng Lv3, Shi-rong Wen4, Sheng Bi4, Wei-zhi Wang1

Affiliation(s):  1. Department of Neurology, the Second Affiliated Hospital, Harbin Medical University, Harbin 150086, China; more

Corresponding email(s):   dwangwz@163.com

Key Words:  Outdoor activity, Vitamin D intake, Parkinson&rsquo, s disease

Dan Zhu, Gui-you Liu, Zheng Lv, Shi-rong Wen, Sheng Bi, Wei-zhi Wang. Inverse associations of outdoor activity and vitamin D intake with the risk of Parkinson’s disease[J]. Journal of Zhejiang University Science B, 2014, 15(10): 923-927.

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publisher="Zhejiang University Press & Springer",

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%T Inverse associations of outdoor activity and vitamin D intake with the risk of Parkinson’s disease
%A Dan Zhu
%A Gui-you Liu
%A Zheng Lv
%A Shi-rong Wen
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T1 - Inverse associations of outdoor activity and vitamin D intake with the risk of Parkinson’s disease
A1 - Dan Zhu
A1 - Gui-you Liu
A1 - Zheng Lv
A1 - Shi-rong Wen
A1 - Sheng Bi
A1 - Wei-zhi Wang
J0 - Journal of Zhejiang University Science B
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DOI - 10.1631/jzus.B1400005

Early studies had suggested that vitamin D intake was inversely associated with neurodegenerative diseases, such as Alzheimer’s disease and multiple sclerosis. However, the associations of vitamin D intake and outdoor activities with parkinson&rsquo;s disease (PD) are still unclear, so this study is to evaluate these relationships from a case-control study in elderly Chinese. The study population involved 209 cases with new onsets of PD and 210 controls without neurodegenerative diseases. The data on dietary vitamin D and outdoor activities were collected using a food-frequency questionnaire and self-report questionnaire. Multivariable logistic regressions were used to examine the associations between dietary outdoor activities, vitamin D intake and PD. Adjustment was made for sex, age, smoking, alcohol use, education, and body mass index (BMI). Adjusted odds ratios (ORs) for PD in quartiles for outdoor physical activity were 1 (reference), 0.739 (0.413, 1.321), 0.501 (0.282, 0.891), and 0.437 (0.241, 0.795), respectively (P=0.002 for trend). Adjusted ORs for PD in quartiles for total vitamin D intake were 1 (reference), 0.647 (0.357, 1.170), 0.571 (0.318, 1.022), and 0.538 (0.301, 0.960), respectively (P=0.011 for trend). Our study suggested that outdoor activity and total vitamin D intake were inversely associated with PD, and outdoor activity seems to be more significantly associated with decreased risk for PD.



Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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