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Received: 2006-05-28

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Journal of Zhejiang University SCIENCE B 2007 Vol.8 No.4 P.242~247


Diffusion tensor imaging of the brain in patients with Alzheimer’s disease and cerebrovascular lesions

Author(s):  CHEN Shao-qiong, KANG Zhuang, HU Xi-quan, HU Bing, ZOU Yan

Affiliation(s):  Department of Radiology, the Third Affiliated Hospital, Sun Yat-Sen University, Guangzhou 510630, China; more

Corresponding email(s):   csq_q@yahoo.com

Key Words:  Diffusion tensor imaging (DTI), Alzheimer&rsquo, s disease (AD), Cerebrovascular, Magnetic resonance imaging (MRI)

CHEN Shao-qiong, KANG Zhuang, HU Xi-quan, HU Bing, ZOU Yan. Diffusion tensor imaging of the brain in patients with Alzheimer’s disease and cerebrovascular lesions[J]. Journal of Zhejiang University Science B, 2007, 8(4): 242~247.

@article{title="Diffusion tensor imaging of the brain in patients with Alzheimer’s disease and cerebrovascular lesions",
author="CHEN Shao-qiong, KANG Zhuang, HU Xi-quan, HU Bing, ZOU Yan",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Diffusion tensor imaging of the brain in patients with Alzheimer’s disease and cerebrovascular lesions
%A CHEN Shao-qiong
%A KANG Zhuang
%A HU Xi-quan
%A HU Bing
%A ZOU Yan
%J Journal of Zhejiang University SCIENCE B
%V 8
%N 4
%P 242~247
%@ 1673-1581
%D 2007
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2007.B0242

T1 - Diffusion tensor imaging of the brain in patients with Alzheimer’s disease and cerebrovascular lesions
A1 - CHEN Shao-qiong
A1 - KANG Zhuang
A1 - HU Xi-quan
A1 - HU Bing
A1 - ZOU Yan
J0 - Journal of Zhejiang University Science B
VL - 8
IS - 4
SP - 242
EP - 247
%@ 1673-1581
Y1 - 2007
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2007.B0242

Background: Recent autopsy study showed a high incidence of cerebrovascular lesions in alzheimer&rsquo;s disease (AD). To assess the impact of cerebrovascular pathology in AD, we used diffusion tensor imaging (DTI) to study AD patients with and without cerebrovascular lesions. Materials and Methods: Conventional and DTI scans were obtained from 10 patients with probable AD, 10 AD/V patients (probable AD with cerebrovascular lesions) and ten normal controls. Mean diffusivity (D) and fractional anisotropy (FA) values of some structures involved with AD pathology were measured. Results: D value was higher in AD patients than in controls in hippocampus and the cingulate gyrus. In AD/V patients, increased D value was found in the same structures and also in the thalamus and basal ganglia compared to controls. There was a significant difference of D value between AD and AD/V patients. FA value reduced in the white matter of left inferior temporal gyrus and in the bilateral middle cingulate gyrus in patients with AD/V compared with controls. The MMSE (mini-mental state examination) score significantly correlated with FA value in the right hippocampus (r=0.639, P<0.019), in the right anterior cingulate gyrus (r=0.587, P<0.035) and in left parahippocampal gyrus (r=0.559, P<0.047). Conclusion: cerebrovascular pathology had stronger impact on the D value than the AD pathology alone did. Elevated D value in thalamic and basal ganglia may contribute to cognitive decline in AD/V patients. Reduced FA values in AD/V patients may indicate that cerebrovascular pathology induced more severe white matter damage than the AD pathology alone did.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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