CLC number:
On-line Access: 2024-07-17
Received: 2023-12-21
Revision Accepted: 2024-03-21
Crosschecked: 2024-07-17
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Xueqing YIN, Xinzhong RUAN, Yongmeng ZHU, Yongfang YIN, Rui HUANG, Chao LIANG. Prediction of peritoneal free cancer cells in gastric cancer patients by golden-angle radial sampling dynamic contrast-enhanced magnetic resonance imaging[J]. Journal of Zhejiang University Science B, 2024, 25(7): 617-627.
@article{title="Prediction of peritoneal free cancer cells in gastric cancer patients by golden-angle radial sampling dynamic contrast-enhanced magnetic resonance imaging",
author="Xueqing YIN, Xinzhong RUAN, Yongmeng ZHU, Yongfang YIN, Rui HUANG, Chao LIANG",
journal="Journal of Zhejiang University Science B",
volume="25",
number="7",
pages="617-627",
year="2024",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2300929"
}
%0 Journal Article
%T Prediction of peritoneal free cancer cells in gastric cancer patients by golden-angle radial sampling dynamic contrast-enhanced magnetic resonance imaging
%A Xueqing YIN
%A Xinzhong RUAN
%A Yongmeng ZHU
%A Yongfang YIN
%A Rui HUANG
%A Chao LIANG
%J Journal of Zhejiang University SCIENCE B
%V 25
%N 7
%P 617-627
%@ 1673-1581
%D 2024
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2300929
TY - JOUR
T1 - Prediction of peritoneal free cancer cells in gastric cancer patients by golden-angle radial sampling dynamic contrast-enhanced magnetic resonance imaging
A1 - Xueqing YIN
A1 - Xinzhong RUAN
A1 - Yongmeng ZHU
A1 - Yongfang YIN
A1 - Rui HUANG
A1 - Chao LIANG
J0 - Journal of Zhejiang University Science B
VL - 25
IS - 7
SP - 617
EP - 627
%@ 1673-1581
Y1 - 2024
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B2300929
Abstract: Objectiveperitoneal free cancer cells can negatively impact disease progression and patient outcomes in gastric cancer. This study aimed to investigate the feasibility of using golden-angle radial sampling dynamic contrast-enhanced magnetic resonance imaging (GRASP DCE-MRI) to predict the presence of peritoneal free cancer cells in gastric cancer patients.
MethodsAll enrolled patients were consecutively divided into analysis and validation groups. Preoperative magnetic resonance imaging (MRI) scans and perfusion were performed in patients with gastric cancer undergoing surgery, and peritoneal lavage specimens were collected for examination. Based on the peritoneal lavage cytology (PLC) results, patients were divided into negative and positive lavage fluid groups. The data collected included clinical and MR information. A nomogram prediction model was constructed to predict the positive rate of peritoneal lavage fluid, and the validity of the model was verified based on data from the verification group.
ResultsThere was no statistical difference between the proportion of PLC-positive cases predicted by GRASP DCE-MR and the actual PLC test. MR tumor stage, tumor thickness, and perfusion parameter Tofts-Ketty model volume transfer constant (Ktrans) were independent predictors of positive peritoneal lavage fluid. The nomogram model featured a concordance index (C-index) of 0.785 and 0.742 for the modeling and validation groups, respectively.
ConclusionsGRASP DCE-MR could effectively predict peritoneal free cancer cells in gastric cancer patients. The nomogram model constructed using these predictors may help clinicians to better predict the risk of peritoneal free cancer cells being present in gastric cancer patients.
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