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On-line Access: 2017-11-06

Received: 2016-10-04

Revision Accepted: 2017-01-15

Crosschecked: 2017-10-12

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Jochen Neuhaus


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Journal of Zhejiang University SCIENCE B 2017 Vol.18 No.11 P.921-933


Nuclear magnetic resonance spectroscopy as a new approach for improvement of early diagnosis and risk stratification of prostate cancer

Author(s):  Bo Yang, Guo-qiang Liao, Xiao-fei Wen, Wei-hua Chen, Sheng Cheng, Jens-Uwe Stolzenburg, Roman Ganzer, Jochen Neuhaus

Affiliation(s):  Department of Urology, Zhoupu Hospital, Shanghai University of Medicine & Health Sciences, Shanghai 201318, China; more

Corresponding email(s):   jochen.neuhaus@medizin.uni-leipzig.de

Key Words:  Prostate cancer, Metabolomics, Nuclear magnetic resonance (NMR), Biomarker

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Bo Yang, Guo-qiang Liao, Xiao-fei Wen, Wei-hua Chen, Sheng Cheng, Jens-Uwe Stolzenburg, Roman Ganzer, Jochen Neuhaus. Nuclear magnetic resonance spectroscopy as a new approach for improvement of early diagnosis and risk stratification of prostate cancer[J]. Journal of Zhejiang University Science B, 2017, 18(11): 921-933.

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author="Bo Yang, Guo-qiang Liao, Xiao-fei Wen, Wei-hua Chen, Sheng Cheng, Jens-Uwe Stolzenburg, Roman Ganzer, Jochen Neuhaus",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

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%T Nuclear magnetic resonance spectroscopy as a new approach for improvement of early diagnosis and risk stratification of prostate cancer
%A Bo Yang
%A Guo-qiang Liao
%A Xiao-fei Wen
%A Wei-hua Chen
%A Sheng Cheng
%A Jens-Uwe Stolzenburg
%A Roman Ganzer
%A Jochen Neuhaus
%J Journal of Zhejiang University SCIENCE B
%V 18
%N 11
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%@ 1673-1581
%D 2017
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1600441

T1 - Nuclear magnetic resonance spectroscopy as a new approach for improvement of early diagnosis and risk stratification of prostate cancer
A1 - Bo Yang
A1 - Guo-qiang Liao
A1 - Xiao-fei Wen
A1 - Wei-hua Chen
A1 - Sheng Cheng
A1 - Jens-Uwe Stolzenburg
A1 - Roman Ganzer
A1 - Jochen Neuhaus
J0 - Journal of Zhejiang University Science B
VL - 18
IS - 11
SP - 921
EP - 933
%@ 1673-1581
Y1 - 2017
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1600441

prostate cancer (PCa) is the second most common male cancer worldwide and the fifth leading cause of death from cancer in men. Early detection and risk stratification is the most effective way to improve the survival of PCa patients. Current PCa biomarkers lack sufficient sensitivity and specificity to cancer. Metabolite biomarkers are evolving as a new diagnostic tool. This review is aimed to evaluate the potential of metabolite biomarkers for early detection, risk assessment, and monitoring of PCa. Of the 154 identified publications, 27 and 38 were original papers on urine and serum metabolomics, respectively. nuclear magnetic resonance (NMR) is a promising method for measuring concentrations of metabolites in complex samples with good reproducibility, high sensitivity, and simple sample processing. Especially urine-based NMR metabolomics has the potential to be a cost-efficient method for the early detection of PCa, risk stratification, and monitoring treatment efficacy.



Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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