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Journal of Zhejiang University SCIENCE B 2020 Vol.21 No.12 P.977-989

http://doi.org/10.1631/jzus.B2000350


Fetal growth, fetal development, and placental features in women with polycystic ovary syndrome: analysis based on fetal and placental magnetic resonance imaging


Author(s):  Qing Zhang, Zhong-kun Bao, Mei-xiang Deng, Qiong Xu, Dan-dan Ding, Man-man Pan, Xi Xi, Fang-fang Wang, Yu Zou, Fan Qu

Affiliation(s):  School of Obstetrics and Gynecology, Zhejiang University School of Medicine, Hangzhou 310006, China; more

Corresponding email(s):   syqufan@zju.edu.cn

Key Words:  Polycystic ovary syndrome (PCOS), Fetus, Magnetic resonance imaging (MRI), Growth and development, Placenta


Qing Zhang, Zhong-kun Bao, Mei-xiang Deng, Qiong Xu, Dan-dan Ding, Man-man Pan, Xi Xi, Fang-fang Wang, Yu Zou, Fan Qu. Fetal growth, fetal development, and placental features in women with polycystic ovary syndrome: analysis based on fetal and placental magnetic resonance imaging[J]. Journal of Zhejiang University Science B, 2020, 21(12): 977-989.

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author="Qing Zhang, Zhong-kun Bao, Mei-xiang Deng, Qiong Xu, Dan-dan Ding, Man-man Pan, Xi Xi, Fang-fang Wang, Yu Zou, Fan Qu",
journal="Journal of Zhejiang University Science B",
volume="21",
number="12",
pages="977-989",
year="2020",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B2000350"
}

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%T Fetal growth, fetal development, and placental features in women with polycystic ovary syndrome: analysis based on fetal and placental magnetic resonance imaging
%A Qing Zhang
%A Zhong-kun Bao
%A Mei-xiang Deng
%A Qiong Xu
%A Dan-dan Ding
%A Man-man Pan
%A Xi Xi
%A Fang-fang Wang
%A Yu Zou
%A Fan Qu
%J Journal of Zhejiang University SCIENCE B
%V 21
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%D 2020
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B2000350

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T1 - Fetal growth, fetal development, and placental features in women with polycystic ovary syndrome: analysis based on fetal and placental magnetic resonance imaging
A1 - Qing Zhang
A1 - Zhong-kun Bao
A1 - Mei-xiang Deng
A1 - Qiong Xu
A1 - Dan-dan Ding
A1 - Man-man Pan
A1 - Xi Xi
A1 - Fang-fang Wang
A1 - Yu Zou
A1 - Fan Qu
J0 - Journal of Zhejiang University Science B
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SP - 977
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B2000350


Abstract: 
Objective: polycystic ovary syndrome (PCOS), a common endocrine-metabolic dysfunction in reproductive-aged women, may be involved in compromised pregnancy and offspring outcomes. This study aimed to investigate whether maternal PCOS affects fetal growth, fetal development, and placental features. Methods: This retrospective case-control study included 60 pregnant women with PCOS (PCOS group) and 120 healthy pregnant women without PCOS (control group). Fetal magnetic resonance imaging (MRI) was performed followed by an ultrasound examination and indications for imaging, including known or suspected fetal pathology, history of fetal abnormality in previous pregnancy or in a family member, and concern for placenta accreta. Fetal MRI images were analyzed for head circumference (HC), abdomen circumference (AC), lung-to-liver signal intensity ratio (LLSIR, a prenatal marker of fetal lung maturity), lengths of liver and kidney diameters in fetuses, and placental relative signal intensity on T2-weighted single-shot fast spin echo (SSFSE) imaging (rSISSFSE), and placental relative apparent diffusion coefficient value (rADC). Data on height and weight of offspring were collected through telephone follow-up. Results: Compared to the control group, the PCOS group showed the following characteristics: (1) smaller biparietal diameter and femur length in fetuses (P=0.026 and P=0.005, respectively), (2) smaller HC in fetuses (evident after 32 weeks; P=0.044), (3) lower LLSIR and smaller dorsoventral length of liver in fetuses (evident before 32 weeks; P=0.005 and P=0.019, respectively), and (4) smaller placental thickness (evident before 32 weeks; P=0.017). No significant differences in placental rSISSFSE or rADC were observed between the groups (all P>0.05). No significant differences in height and weight of offspring during childhood existed between the groups (all P>0.05). Conclusions: There exist alterations of fetal growth, fetal development, and placental features from women with PCOS.

多囊卵巢综合征女性孕期的胎儿生长发育和胎盘特征:基于胎儿和胎盘磁共振成像分析

目的:探讨母亲多囊卵巢综合征(PCOS)对子代胎儿期生长发育和胎盘特征的影响.
创新点:首次关注到PCOS女性孕期的胎儿和胎盘磁共振成像(MRI)特征,通过影像学和临床疾病的结合,对胎儿和胎盘MRI图像进行全面分析和测量,评估胎儿生长发育和胎盘特征,并追踪产科和子代随访结局,以期为PCOS对子代的潜在影响提供科学依据.
方法:本研究对浙江大学医学院附属妇产科医院2013~2018年行胎儿MRI检查的妊娠女性病例行回顾性分析,根据鹿特丹诊断标准纳入PCOS妊娠女性60例,随机选取与其胎儿MRI检查孕周相匹配的非PCOS妊娠女性120例作为对照,收集胎儿和胎盘MRI图像信息,统计学分析比较PCOS妊娠女性与非PCOS妊娠女性影像学测量指标,包括胎儿的双顶径、头围、腹围、肝脏和肾脏各径线,胎儿肺和肝的信号强度,胎盘异常情况、胎盘厚度、胎盘信号强度和表观扩散系数值(ADC),并比较分析人口学数据、产科和新生儿结局,随访子代儿童期的生长情况.
结论:母亲PCOS会造成子代胎儿期生长发育和胎盘特征的改变.因本研究为回顾性研究、样本量偏小及一些潜在的偏差,结论有待进一步证实.

关键词:多囊卵巢综合征;胎儿;核磁共振成像;生长发育;胎盘

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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