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On-line Access: 2023-08-18
Received: 2022-12-29
Revision Accepted: 2023-03-30
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Xueqing WANG, Dong YU, Yong WU, Qianming DING, Tianyu LI, Ya JIA. Effects of potassium channel blockage on inverse stochastic resonance in Hodgkin-Huxley neural systems[J]. Journal of Zhejiang University Science A,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.A2200625 @article{title="Effects of potassium channel blockage on inverse stochastic resonance in Hodgkin-Huxley neural systems", %0 Journal Article TY - JOUR
钾离子通道阻塞对Hodgkin-Huxley神经系统中反随机共振的影响机构:华中师范大学,物理系,中国武汉,430079 目的:研究钾离子通道阻塞对单个Hodgkin-Huxley神经元和小世界网络中反随机共振(ISR)的影响,并分析背后的动力学机制。 创新点:1.探究钾离子通道阻塞对反随机共振的影响;2.在小世界网络中考虑阻塞不均匀对反随机共振的影响。 方法:1.以放电率作为统计量,研究钾离子通道阻塞对神经元放电率的影响(图2和3);2.通过分岔分析,探究钾离子通道阻塞对反随机共振所产生影响背后的动力学机制(图4);3.探究部分阻塞的神经元网络中反随机共振对耦合强度的依赖性(图8和13);4.通过相空间和网络中神经元的放电分布等分析不同反随机共振曲线背后的动力学机制(图10~12)。 结论:1.对于单个神经元,离子通道噪声引起的ISR现象只发生在较小的钾离子通道阻塞率范围内;分岔分析表明这一小范围是受外部偏置电流影响的双稳态区域。2.对于小世界神经元网络,ISR存在的原因是在中等强度噪声下双稳态神经元的放电受到抑制。3.当双稳态和单稳态神经元之间存在电位差,且耦合强度增加时,抑制作用被抵消。4.在较小的耦合强度下,网络阻塞比的增加会导致ISR持续时间变短;当耦合强度增加时,ISR在网络阻塞比较大的情况下更为明显;ISR现象由网络阻塞比、耦合强度和离子通道噪声共同决定。 关键词组: Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article
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