CLC number: R392.4
On-line Access: 2019-09-06
Received: 2019-04-28
Revision Accepted: 2019-07-15
Crosschecked: 2019-08-14
Cited: 0
Clicked: 3217
Bing Hao, Song Gao, Yi-Wen Sang, Lin Wang, Xue-Qin Meng, Jing-Ya You. Potential value of autoantibodies as biomarkers of chronic graft-versus-host disease after allogeneic stem cell transplantation[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B1900205 @article{title="Potential value of autoantibodies as biomarkers of chronic graft-versus-host disease after allogeneic stem cell transplantation", %0 Journal Article TY - JOUR
自身抗体作为异基因造血干细胞移植后慢性移植物抗宿主病的生物学标志物的潜在价值研究创新点:我们创新性地应用了包含核仁形成区抗原成分的自身抗体谱对各实验组进行了超过30种自身抗体的筛查,首次发现anti-Ro52抗体可能与肝脏cGVHD有关. 方法:联合应用间接免疫荧光、线性免疫印迹和酶联免疫吸附试验(ELISA)对各实验组进行自身抗体谱筛查,采用统计学软件对实验结果和临床数据进行比对分析. 结论:我们的研究证实异基因造血干细胞移植后各组病人都可能出现以核仁型抗核抗体(ANA)为主的自身抗体表达增高,并且anti-Ro52抗体在肝脏cGVHD病人血清中显著增高,然而自身抗体与cGVHD的活动性、严重程度和预后均无明显相关性.我们的研究结果表明,自身抗体在预测cGVHD方面的价值有限. 关键词组: Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article
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