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On-line Access: 2023-08-11

Received: 2023-02-14

Revision Accepted: 2023-06-24

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Journal of Zhejiang University SCIENCE B

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Defense and anti-defense mechanisms of bacteria and bacteriophages


Author(s):  Xiaoqing WANG, Sebastian LEPTIHN

Affiliation(s):  School of Medicine, Lishui University, Lishui, 323000, China; more

Corresponding email(s):  sebastian.leptihn@health-and-medical-university.de, 11818142@zju.edu.cn

Key Words:  Bacteriophage; Phage resistance; Abortive infection; Phage therapy


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Xiaoqing WANG, Sebastian LEPTIHN. Defense and anti-defense mechanisms of bacteria and bacteriophages[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2300101

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Abstract: 
In the post-antibiotic era, the overuse of antimicrobials has led to a massive increase in antimicrobial resistance leaving medical doctors few or no treatment options to fight infections caused by superbugs. The use of bacteriophages is a promising alternative to treat infections, supplementing or possibly even replacing antibiotics. Using phages for therapy is possible, since these bacterial viruses can kill bacteria specifically, causing no harm to the normal flora. However, bacteria have developed a multitude of sophisticated and complex ways to resist infection by phages, including abortive infection and the fascinating CRISPR-Cas system. Phages also can evolve and acquire new anti-defense strategies to continue predation. An in-depth exploration of both defense and anti-defense mechanisms would contribute to optimizing phage therapy, while we would also gain novel insights into the microbial world. In this paper, we summarize recent research on bacterial phage resistance and phage anti-defense mechanisms, as well as collaborative win-win systems involving both virus and host.

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