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 ORCID:

Qian GONG

https://orcid.org/0000-0001-8587-4185

Lenan ZHUANG

https://orcid.org/0000-0001-9561-8396

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Journal of Zhejiang University SCIENCE B

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Therapeutic advances in atrial fibrillation based on animal models


Author(s):  Qian GONG, Xuan LE, Pengcheng YU, Lenan ZHUANG

Affiliation(s):  Institute of Genetics and Reproduction, College of Animal Sciences, Zhejiang University,Hangzhou310058,China; more

Corresponding email(s):  zhuangln@zju.edu.cn

Key Words:  Atrial fibrillation; Animal model; Therapeutic


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Qian GONG, Xuan LE, Pengcheng YU, Lenan ZHUANG. Therapeutic advances in atrial fibrillation based on animal models[J]. Journal of Zhejiang University Science B,in press.Frontiers of Information Technology & Electronic Engineering,in press.https://doi.org/10.1631/jzus.B2300285

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%A Qian GONG
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T1 - Therapeutic advances in atrial fibrillation based on animal models
A1 - Qian GONG
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Abstract: 
Atrial fibrillation (AF) is the most prevalent sustained cardiac arrhythmia among humans, with its incidence increasing significantly with age. Despite the high frequency of AF in clinical practice, its etiology and management remain elusive. To develop effective treatment strategies, it is imperative to comprehend the underlying mechanisms of AF; therefore, the establishment of animal models of AF is vital to explore its pathogenesis. While spontaneous AF is rare in most animal species, several large animal models, particularly those of pigs, dogs, and horses, have proven as invaluable in recent years in advancing our knowledge of AF pathogenesis and developing novel therapeutic options. This review aims to provide a comprehensive discussion of various animal models of AF, with an emphasis on the unique features of each model and its utility in AF research and treatment. The data summarized in this review provide valuable insights into the mechanisms of AF and can be used to evaluate the efficacy and safety of novel therapeutic interventions.

基于动物模型的房颤治疗进展

巩倩1,2,乐萱1,余鹏程2,庄乐南1,2
1浙江大学动物科学学院遗传与繁殖研究所,中国杭州市,310058
2浙江大学医学院邵逸夫医院心血管介入与再生医学浙江省重点实验室,心内科,中国杭州市,310016
摘要:心房颤动(Atrial fibrillation, AF)是人类最常见的由持续性心律失常导致的心脏疾病,其发病率随着年龄增长而显著增加。尽管房颤在临床实践中很常见,但其病因和治疗尚不清晰。为了制定有效的治疗策略,必须了解房颤的基本机制,因此建立房颤的动物模型对于探索其发病机制至关重要。虽然自发性房颤在大多数动物中罕见,但近年来一些大型动物模型,特别是猪、狗和马模型,已被证明在推进我们对房颤发病机制认识和开发新的治疗方案方面非常宝贵。本综述旨在对房颤的各种动物模型进行全面讨论,重点介绍每种模型的特征及其在房颤研究和治疗中的效用。本综述为房颤机制提供了宝贵的见解,并可用于评估新型治疗干预措施的有效性和安全性。

关键词组:房颤;动物模型;治疗

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

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