Journal of Zhejiang University

Journal of Zhejiang University SCIENCE B 2014 Vol.15 No.10 P.845-863

Therapeutic radionuclides in nuclear medicine: current and future prospects

Author(s): Chai-Hong Yeong¹,Mu-hua Cheng²,Kwan-Hoong Ng¹
Affiliation(s): 1. 1. Department of Biomedical Imaging & University of Malaya Research Imaging Centre, Faculty of Medicine, University of Malaya, Kuala Lumpur 50603, Malaysia more
Corresponding email(s): chyeong@um.edu.my
Key Words: Therapeutic radionuclide, Targeted radionuclide therapy, Radioimmunotherapy, Molecular targeting, Theranostics

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Chai-Hong Yeong, Mu-hua Cheng, Kwan-Hoong Ng. Therapeutic radionuclides in nuclear medicine: current and future prospects[J]. Journal of Zhejiang University Science B, 2014, 15(10): 845-863.

@article{title="Therapeutic radionuclides in nuclear medicine: current and future prospects",
author="Chai-Hong Yeong, Mu-hua Cheng, Kwan-Hoong Ng",
journal="Journal of Zhejiang University Science B",
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number="10",
pages="845-863",
year="2014",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1400131"
}

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PB - Zhejiang University Press & Springer
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Abstract
Chinese Summary
Academic Network
Reviewer Comment

Abstract: The potential use of radionuclides in therapy has been recognized for many decades. A number of radionuclides, such as iodine-131 (¹³¹I), phosphorous-32 (³²P), strontium-90 (⁹⁰Sr), and yttrium-90 (⁹⁰Y), have been used successfully for the treatment of many benign and malignant disorders. Recently, the rapid growth of this branch of nuclear medicine has been stimulated by the introduction of a number of new radionuclides and radiopharmaceuticals for the treatment of metastatic bone pain and neuroendocrine and other malignant or non-malignant tumours. Today, the field of radionuclide therapy is enjoying an exciting phase and is poised for greater growth and development in the coming years. For example, in Asia, the high prevalence of thyroid and liver diseases has prompted many novel developments and clinical trials using targeted radionuclide therapy. This paper reviews the characteristics and clinical applications of the commonly available therapeutic radionuclides, as well as the problems and issues involved in translating novel radionuclides into clinical therapies.

核医学放射性核素治疗的研究现状及前景

本文目的：本文综述了临床常用的放射性治疗方式和应用现状以及新的放射性核素从科研至临床应用所存在的问题。
本文概要：放射性核素的临床应用及研究已历数十载，已有碘-131、磷-32、锶-90及钇-90等众多放射性核素被成功用于治疗良恶性疾病。随着新的放射性核素及药物不断应用于骨转移瘤疼痛治疗、神经内分泌肿瘤及其他良恶性肿瘤治疗，放射性核素治疗得到了快速发展。目前，放射性核素治疗已进入蓬勃发展期；在亚洲，由于甲状腺和肝脏肿瘤的高发病率，促进了放射性核素治疗及其靶向治疗研究的日益发展。随着放射性核素与其他药物的联合应用，放射性核素治疗肿瘤的临床价值必将显著提高。
核医学；核素治疗；靶向治疗；放射性药物；放射性核素治疗