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On-line Access: 2024-08-27

Received: 2023-10-17

Revision Accepted: 2024-05-08

Crosschecked: 2023-02-09

Cited: 0

Clicked: 1886

Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Yunzi ZHAO

https://orcid.org/0000-0001-7466-3833

Hui HUI

https://orcid.org/0000-0002-3257-0708

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Journal of Zhejiang University SCIENCE B 2023 Vol.24 No.2 P.101-114

http://doi.org/10.1631/jzus.B2200178


Multiple characteristic alterations and available therapeutic strategies of cellular senescence


Author(s):  Yunzi ZHAO, Hui LI, Qinglong GUO, Hui HUI

Affiliation(s):  State Key Laboratory of Natural Medicines, Jiangsu Key Laboratory of Carcinogenesis and Intervention, China Pharmaceutical University, Nanjing 210009, China

Corresponding email(s):   moyehh@163.com

Key Words:  Senescence, Metabolism, Stemness, Microenvironment, Senolytic, Immune surveillance


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Abstract: 
Given its state of stable proliferative inhibition, cellular senescence is primarily depicted as a critical mechanism by which organisms delay the progression of carcinogenesis. Cells undergoing senescence are often associated with the alteration of a series of specific features and functions, such as metabolic shifts, stemness induction, and microenvironment remodeling. However, recent research has revealed more complexity associated with senescence, including adverse effects on both physiological and pathological processes. How organisms evade these harmful consequences and survive has become an urgent research issue. Several therapeutic strategies targeting senescence, including senolytics, senomorphics, immunotherapy, and function restoration, have achieved initial success in certain scenarios. In this review, we describe in detail the characteristic changes associated with cellular senescence and summarize currently available countermeasures.

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