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On-line Access: 2021-09-22
Received: 2021-05-13
Revision Accepted: 2021-08-16
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From hardware store to hospital: a COVID-19-inspired, cost-effective, open-source, in vivo-validated ventilator for use in resource-scarce regions
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Matthew H. Park, Yuanjia Zhu, Hanjay Wang, Nicholas A. Tran, Jinsuh Jung, Michael J. Paulsen, Annabel M. Imbrie-Moore, Samuel Baker, Robert Wilkerson, Mateo Marin-Cuartas, Danielle M. Mullis & Y. Joseph Woo. From hardware store to hospital: a COVID-19-inspired, cost-effective, open-source, in vivo-validated ventilator for use in resource-scarce regions[J]. Journal of Zhejiang University Science D, 2022, 5(1): 133-140.
@article{title="From hardware store to hospital: a COVID-19-inspired, cost-effective, open-source, in vivo-validated ventilator for use in resource-scarce regions",
author="Matthew H. Park, Yuanjia Zhu, Hanjay Wang, Nicholas A. Tran, Jinsuh Jung, Michael J. Paulsen, Annabel M. Imbrie-Moore, Samuel Baker, Robert Wilkerson, Mateo Marin-Cuartas, Danielle M. Mullis & Y. Joseph Woo",
journal="Journal of Zhejiang University Science D",
volume="5",
number="1",
pages="133-140",
year="2022",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-021-00164-1"
}
%0 Journal Article
%T From hardware store to hospital: a COVID-19-inspired, cost-effective, open-source, in vivo-validated ventilator for use in resource-scarce regions
%A Matthew H. Park
%A Yuanjia Zhu
%A Hanjay Wang
%A Nicholas A. Tran
%A Jinsuh Jung
%A Michael J. Paulsen
%A Annabel M. Imbrie-Moore
%A Samuel Baker
%A Robert Wilkerson
%A Mateo Marin-Cuartas
%A Danielle M. Mullis & Y. Joseph Woo
%J Journal of Zhejiang University SCIENCE D
%V 5
%N 1
%P 133-140
%@ 1869-1951
%D 2022
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-021-00164-1
TY - JOUR
T1 - From hardware store to hospital: a COVID-19-inspired, cost-effective, open-source, in vivo-validated ventilator for use in resource-scarce regions
A1 - Matthew H. Park
A1 - Yuanjia Zhu
A1 - Hanjay Wang
A1 - Nicholas A. Tran
A1 - Jinsuh Jung
A1 - Michael J. Paulsen
A1 - Annabel M. Imbrie-Moore
A1 - Samuel Baker
A1 - Robert Wilkerson
A1 - Mateo Marin-Cuartas
A1 - Danielle M. Mullis & Y. Joseph Woo
J0 - Journal of Zhejiang University Science D
VL - 5
IS - 1
SP - 133
EP - 140
%@ 1869-1951
Y1 - 2022
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-021-00164-1
Abstract: Resource-scarce regions with serious COVID-19 outbreaks do not have enough ventilators to support critically ill patients, and these shortages are especially devastating in developing countries. To help alleviate this strain, we have designed and tested the accessible low-barrier in vivo-validated economical ventilator (ALIVE Vent), a COVID-19-inspired, cost-effective, open-source, in vivo-validated solution made from commercially available components. The ALIVE Vent operates using compressed oxygen and air to drive inspiration, while two solenoid valves ensure one-way flow and precise cycle timing. The device was functionally tested and profiled using a variable resistance and compliance artificial lung and validated in anesthetized large animals. Our functional test results revealed its effective operation under a wide variety of ventilation conditions defined by the American Association of Respiratory Care guidelines for ventilator stockpiling. The large animal test showed that our ventilator performed similarly if not better than a standard ventilator in maintaining optimal ventilation status. The FiO2, respiratory rate, inspiratory to expiratory time ratio, positive-end expiratory pressure, and peak inspiratory pressure were successfully maintained within normal, clinically validated ranges, and the animals were recovered without any complications. In regions with limited access to ventilators, the ALIVE Vent can help alleviate shortages, and we have ensured that all used materials are publicly available. While this pandemic has elucidated enormous global inequalities in healthcare, innovative, cost-effective solutions aimed at reducing socio-economic barriers, such as the ALIVE Vent, can help enable access to prompt healthcare and life saving technology on a global scale and beyond COVID-19.
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