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On-line Access: 2019-04-15
Received: 2018-04-29
Revision Accepted: 2018-06-20
Crosschecked: 2019-03-14
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Current advances in solid free-form techniques for osteochondral tissue engineering
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João Bebiano Costa, Joana Silva-Correia, Rui Luís Reis, Joaquim Miguel Oliveira. Current advances in solid free-form techniques for osteochondral tissue engineering[J]. Journal of Zhejiang University Science D, 2018, 1(3): 171-181.
@article{title="Current advances in solid free-form techniques for osteochondral tissue engineering",
author="João Bebiano Costa, Joana Silva-Correia, Rui Luís Reis, Joaquim Miguel Oliveira",
journal="Journal of Zhejiang University Science D",
volume="1",
number="3",
pages="171-181",
year="2018",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-018-0017-y"
}
%0 Journal Article
%T Current advances in solid free-form techniques for osteochondral tissue engineering
%A João Bebiano Costa
%A Joana Silva-Correia
%A Rui Luís Reis
%A Joaquim Miguel Oliveira
%J Journal of Zhejiang University SCIENCE D
%V 1
%N 3
%P 171-181
%@ 1869-1951
%D 2018
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-018-0017-y
TY - JOUR
T1 - Current advances in solid free-form techniques for osteochondral tissue engineering
A1 - João Bebiano Costa
A1 - Joana Silva-Correia
A1 - Rui Luís Reis
A1 - Joaquim Miguel Oliveira
J0 - Journal of Zhejiang University Science D
VL - 1
IS - 3
SP - 171
EP - 181
%@ 1869-1951
Y1 - 2018
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-018-0017-y
Abstract: Osteochondral (OC) lesions are characterized by defects in two different zones, the cartilage region and subchondral bone region. These lesions are frequently associated with mechanical instability, as well as osteoarthritic degenerative changes in the knee. The lack of spontaneous healing and the drawbacks of the current treatments have increased the attention from the scientific community to this issue. Different tissue engineering approaches have been attempted using different polymers and different scaffolds’ processing. However, the current conventional techniques do not allow the full control over scaffold fabrication, and in this type of approaches, the tuning ability is the key to success in tissue regeneration. In this sense, the researchers have placed their efforts in the development of solid free-form (SFF) techniques. These techniques allow tuning different properties at the micro–macro scale, creating scaffolds with appropriate features for OC tissue engineering. In this review, it is discussed the current SFF techniques used in OC tissue engineering and presented their promising results and current challenges.
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