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Bio-Design and Manufacturing  2020 Vol.3 No.3 P.252-265

http://doi.org/10.1007/s42242-020-00077-5


Fabrication of paper-based devices for in vitro tissue modeling


Author(s):  Hongbin Li, Feng Cheng, Juan A. Robledo-Lara, Junlong Liao, Zixuan Wang, Yu Shrike Zhang

Affiliation(s):  Division of Engineering in Medicine, Department of Medicine, Brigham and Women’s Hospital, Harvard Medical School, Cambridge, MA 02139, USA; more

Corresponding email(s):   yszhang@research.bwh.harvard.edu

Key Words:  Paper-based devices, In vitro, Tissue modeling, Disease modeling, Drug screening, Personalized medicine


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Hongbin Li, Feng Cheng, Juan A. Robledo-Lara, Junlong Liao, Zixuan Wang, Yu Shrike Zhang. Fabrication of paper-based devices for in vitro tissue modeling[J]. Journal of Zhejiang University Science D, 2020, 3(3): 252-265.

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author="Hongbin Li, Feng Cheng, Juan A. Robledo-Lara, Junlong Liao, Zixuan Wang, Yu Shrike Zhang",
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doi="10.1007/s42242-020-00077-5"
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Abstract: 
Paper devices have recently attracted considerable attention as a class of cost-effective cell culture substrates for various biomedical applications. The paper biomaterial can be used to partially mimic the in vivo cell microenvironments mainly due to its natural three-dimensional characteristic. The paper-based devices provide precise control over their structures as well as cell distributions, allowing recapitulation of certain interactions between the cells and the extracellular matrix. These features have shown great potential for the development of normal and diseased human tissue models. In this review, we discuss the fabrication of paper-based devices for in vitro tissue modeling, as well as the applications of these devices toward drug screening and personalized medicine. It is believed that paper as a biomaterial will play an essential role in the field of tissue model engineering due to its unique performances, such as good biocompatibility, eco-friendliness, cost-effectiveness, and amenability to various biodesign and manufacturing needs.

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