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On-line Access: 2021-08-09
Received: 2020-11-12
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Organoids: a novel modality in disease modeling
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Zahra Heydari, Farideh Moeinvaziri, Tarun Agarwal, Paria Pooyan, Anastasia Shpichka, Tapas K. Maiti, Peter Timashev, Hossein Baharvand, Massoud Vosough. Organoids: a novel modality in disease modeling[J]. Journal of Zhejiang University Science D, 2021, 4(4): 689-716.
@article{title="Organoids: a novel modality in disease modeling",
author="Zahra Heydari, Farideh Moeinvaziri, Tarun Agarwal, Paria Pooyan, Anastasia Shpichka, Tapas K. Maiti, Peter Timashev, Hossein Baharvand, Massoud Vosough",
journal="Journal of Zhejiang University Science D",
volume="4",
number="4",
pages="689-716",
year="2021",
publisher="Zhejiang University Press & Springer",
doi="10.1007/s42242-021-00150-7"
}
%0 Journal Article
%T Organoids: a novel modality in disease modeling
%A Zahra Heydari
%A Farideh Moeinvaziri
%A Tarun Agarwal
%A Paria Pooyan
%A Anastasia Shpichka
%A Tapas K. Maiti
%A Peter Timashev
%A Hossein Baharvand
%A Massoud Vosough
%J Journal of Zhejiang University SCIENCE D
%V 4
%N 4
%P 689-716
%@ 1869-1951
%D 2021
%I Zhejiang University Press & Springer
%DOI 10.1007/s42242-021-00150-7
TY - JOUR
T1 - Organoids: a novel modality in disease modeling
A1 - Zahra Heydari
A1 - Farideh Moeinvaziri
A1 - Tarun Agarwal
A1 - Paria Pooyan
A1 - Anastasia Shpichka
A1 - Tapas K. Maiti
A1 - Peter Timashev
A1 - Hossein Baharvand
A1 - Massoud Vosough
J0 - Journal of Zhejiang University Science D
VL - 4
IS - 4
SP - 689
EP - 716
%@ 1869-1951
Y1 - 2021
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1007/s42242-021-00150-7
Abstract: Limitations of monolayer culture conditions have motivated scientists to explore new models that can recapitulate the architecture and function of human organs more accurately. Recent advances in the improvement of protocols have resulted in
establishing three-dimensional (3D) organ-like architectures called ‘organoids’ that can display the characteristics of their
corresponding real organs, including morphological features, functional activities, and personalized responses to specifc
pathogens. We discuss diferent organoid-based 3D models herein, which are classifed based on their original germinal layer.
Studies of organoids simulating the complexity of real tissues could provide novel platforms and opportunities for generating
practical knowledge along with preclinical studies, including drug screening, toxicology, and molecular pathophysiology of
diseases. This paper also outlines the key challenges, advantages, and prospects of current organoid systems.
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