Full Text:   <2804>

Summary:  <1955>

CLC number: R736.1

On-line Access: 2024-08-27

Received: 2023-10-17

Revision Accepted: 2024-05-08

Crosschecked: 2017-04-10

Cited: 0

Clicked: 5376

Citations:  Bibtex RefMan EndNote GB/T7714

-   Go to

Article info.
Open peer comments

Journal of Zhejiang University SCIENCE B 2017 Vol.18 No.5 P.430-436

http://doi.org/10.1631/jzus.B1600308


Clinical characteristics and treatment of thyroid cancer in children and adolescents: a retrospective analysis of 83 patients


Author(s):  Xiao-chun Mao, Wen-qiao Yu, Jin-biao Shang, Ke-jing Wang

Affiliation(s):  Department of Head and Neck Surgery, Zhejiang Cancer Hospital, Hangzhou 310011, China; more

Corresponding email(s):   maoxiaochun@hotmail.com, Wangkejing2016@hotmail.com

Key Words:  Children and adolescents, Thyroid cancer, Clinical characteristics, Surgical treatment


Xiao-chun Mao, Wen-qiao Yu, Jin-biao Shang, Ke-jing Wang. Clinical characteristics and treatment of thyroid cancer in children and adolescents: a retrospective analysis of 83 patients[J]. Journal of Zhejiang University Science B, 2017, 18(5): 430-436.

@article{title="Clinical characteristics and treatment of thyroid cancer in children and adolescents: a retrospective analysis of 83 patients",
author="Xiao-chun Mao, Wen-qiao Yu, Jin-biao Shang, Ke-jing Wang",
journal="Journal of Zhejiang University Science B",
volume="18",
number="5",
pages="430-436",
year="2017",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B1600308"
}

%0 Journal Article
%T Clinical characteristics and treatment of thyroid cancer in children and adolescents: a retrospective analysis of 83 patients
%A Xiao-chun Mao
%A Wen-qiao Yu
%A Jin-biao Shang
%A Ke-jing Wang
%J Journal of Zhejiang University SCIENCE B
%V 18
%N 5
%P 430-436
%@ 1673-1581
%D 2017
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B1600308

TY - JOUR
T1 - Clinical characteristics and treatment of thyroid cancer in children and adolescents: a retrospective analysis of 83 patients
A1 - Xiao-chun Mao
A1 - Wen-qiao Yu
A1 - Jin-biao Shang
A1 - Ke-jing Wang
J0 - Journal of Zhejiang University Science B
VL - 18
IS - 5
SP - 430
EP - 436
%@ 1673-1581
Y1 - 2017
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.B1600308


Abstract: 
Objective: To study the clinical characteristics, treatment, and prognosis of thyroid cancer in children and adolescents. Methods: We performed a retrospective analysis of clinical data from 83 cases of thyroid cancer in children and adolescents from January 1990 to December 2010. We compared extra-thyroid extension, lymph node metastasis, distant metastasis, and prognosis between pediatric patients ≤12 years of age (27 cases) and those >12 years of age (56 cases). All the patients agreed to undergo thyroidectomy and endocrine therapy, and the consent was obtained from parents or guardians. Results: Histopathology included papillary carcinoma in 67 cases, papillary carcinoma with partial follicular growth pattern in 1 case, papillary carcinoma with squamous metaplasia in 4 cases, follicular carcinoma in 7 cases, medullary carcinoma in 3 cases, and poorly differentiated carcinoma in 1 case. The total lymph node metastasis rate was 78.31%. Patients ≤12 years of age showed a higher rate of lymph node metastasis than the older group (92.59% vs. 71.43%, P=0.028). The incidence rate in females in the older group was higher than that in the younger group (80.36% vs. 59.26%, P=0.041). There were no significant differences in extra-thyroid extension, distant metastasis, survival rate, or recurrent disease between the two groups. Conclusions: The lymph node metastasis of thyroid cancer is higher in patients ≤12 years of age than in those >12 years of age; the incidence rate is higher in females than in males. Childhood thyroid cancer has a good prognosis, surgery being the most effective treatment. Choosing a reasonable surgery method and comprehensive postoperative treatment can achieve a cure and satisfactory survival rate.

回顾性分析83例青少年甲状腺癌患者的临床特征和治疗体会

目的:通过对青少年甲状腺癌患者的临床特征、治疗方法以及患者预后的分析和总结,为将来青少年甲状腺癌的治疗提供合理的治疗思路和方法。
创新点:回顾20年的青少年甲状腺癌患者的临床特征和治疗方式,分析治疗模式和观念的衍变,结合指南推荐,总结本中心对青少年甲状腺癌的治疗体会和经验,为青少年甲状腺癌患者提供更合理的治疗方式。
方法:回顾性分析本中心1990年1月至2010年12月期间收治的青少年甲状腺癌患者,并对其预后进行随访。根据年龄以12岁为界分成≤12岁和>12岁两组,分析两组患者的发病率、淋巴结转移、远处转移、腺外侵犯、治疗方法和预后情况。
结论:所有青少年甲状腺癌患者以分化型癌为主,小于12岁患者的淋巴结转移率要明显高于大于12岁组,同时在高龄组的患者中,女性的发病率要高于男性。在腺外侵犯、远处转移、死亡率以及复发性疾病等其他方面,两组无显著性差异。青少年甲状腺癌患者的总体预后较好,选择手术为主的综合性治疗方式将会得到较为满意的效果。

关键词:青少年;甲状腺癌;临床特征;手术治疗

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

[1]Adam, M.A., Pura, J., Gu, L., et al., 2014. Extent of surgery for papillary thyroid cancer is not associated with survival: an analysis of 61 775 patients. Ann. Surg., 260(4):601-607.

[2]Alessandri, A.J., Goddard, K.J., Blair, G.K., et al., 2000. Age is the major determinant of recurrence in pediatric differentiated thyroid carcinoma. Med. Pediatr. Oncol., 35(1):41-46.

[3]Atabek, M.E., 2011. What is the safe and accurate procedure for thyroid nodules in childhood? Horm. Res. Paediatr., 76(1):72.

[4]Baş, V.N., Aycan, Z., Çetinkaya, S., et al., 2012. Thyroid nodules in children and adolescents: a single institution’s experience. J. Pediatr. Endocrinol. Metab., 25(7-8):633-638.

[5]Dzepina, D., 2012. Surgical and pathological characteristics of papillary thyroid cancer in children and adolescents. Int. J. Pediatr., 2012:125389.

[6]Dzodic, R., Buta, M., Markovic, I., et al., 2014. Surgical management of well-differentiated thyroid carcinoma in children and adolescents: 33 years of experience of a single institution in Serbia. Endocr. J., 61(11):1079-1086.

[7]Edge, S.B., Compton, C.C., 2010. The American Joint Committee on Cancer: the 7th edition of the AJCC Cancer Staging Manual and the future of TNM. Ann. Surg. Oncol., 17(6):1471-1474.

[8]Francis, G.L., Waguespack, S.G., Bauer, A.J., et al., 2015. Management guidelines for children with thyroid nodules and differentiated thyroid cancer. Thyroid, 25(7):716-759.

[9]Grigsby, P.W., Gal-or, A., Michalski, J.M., et al., 2002. Childhood and adolescent thyroid carcinoma. Cancer, 95(4):724-729.

[10]Gupta, A., Ly, S., Castroneves, L.A., et al., 2013. A standardized assessment of thyroid nodules in children confirms higher cancer prevalence than in adults. J. Clin. Endocrinol. Metab., 98(8):3238-3245.

[11]Jing, F.J., Liang, Z.Y., Long, W., et al., 2013. Invasive capacity of differentiated thyroid carcinoma in pediatric and adolescent patients. Acta Acad. Med. Sin., 35(1):80-83 (in Chinese).

[12]Kloos, R.T., Eng, C., Evans, D.B., et al., 2009. Medullary thyroid cancer: management guidelines of the American Thyroid Association. Thyroid, 19(6):565-612.

[13]Leboulleux, S., Hartl, D., Baudin, E., et al., 2012. Differentiated thyroid cancer in childhood. Bull. Cancer, 99(11): 1093-1099 (in French).

[14]Mihailovic, J., Stefanovic, L., Malesevic, M., 2007. Differentiated thyroid carcinoma with distant metastases: probability of survival and its predicting factors. Cancer Biother. Radiopharm., 22(2):250-255.

[15]Mihailovic, J., Stefanovic, L., Malesevic, M., et al., 2009. The importance of age over radioiodine avidity as a prognostic factor in differentiated thyroid carcinoma with distant metastases. Thyroid, 19(3):227-232.

[16]Mihailovic, J., Nikoletic, K., Srbovan, D., 2014. Recurrent disease in juvenile differentiated thyroid carcinoma: prognostic factors, treatments, and outcomes. J. Nucl. Med., 55(5):710-717.

[17]O'Gorman, C.S., Hamilton, J., Rachmiel, M., et al., 2010. Thyroid cancer in childhood: a retrospective review of childhood course. Thyroid, 20(4):375-380.

[18]Osipoff, J.N., Wilson, T.A., 2012. Consultation with the specialist: thyroid nodules. Pediatr. Rev., 33(2):75-81; quiz 82.

[19]Patron, V., Bedfer, C., le Clech, G., et al., 2011. Pattern of lateral neck metastases in N0 papillary thyroid carcinoma. BMC Cancer, 11:8.

[20]Schlumberger, M., Sherman, S.I., 2012. Approach to the patient with advanced differentiated thyroid cancer. Eur. J. Endocrinol., 166(1):5-11.

[21]Vaisman, F., Corbo, R., Vaisman, M., 2011. Thyroid carcinoma in children and adolescents—systematic review of the literature. J. Thyroid Res., 2011:845362.

[22]Ward, L.S., Marrone, M., Camargo, R.Y., et al., 2006. Low-risk differentiated thyroid carcinoma—literature review and management guidelines. Arq. Bras. Endocrinol. Metabol., 50(3):550-557 (in Portuguese).

Open peer comments: Debate/Discuss/Question/Opinion

<1>

Please provide your name, email address and a comment





Journal of Zhejiang University-SCIENCE, 38 Zheda Road, Hangzhou 310027, China
Tel: +86-571-87952783; E-mail: cjzhang@zju.edu.cn
Copyright © 2000 - 2024 Journal of Zhejiang University-SCIENCE