Full Text:   <2201>

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CLC number: R737.33

On-line Access: 2015-05-04

Received: 2014-09-22

Revision Accepted: 2015-01-16

Crosschecked: 2015-04-22

Cited: 2

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Citations:  Bibtex RefMan EndNote GB/T7714


Xiang Zhang


Yue Yang


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Journal of Zhejiang University SCIENCE B 2015 Vol.16 No.5 P.388-394


Treatment and prognosis of cervical cancer associated with pregnancy: analysis of 20 cases from a Chinese tumor institution

Author(s):  Xiang Zhang, Yong-liang Gao, Yue Yang

Affiliation(s):  Department of Gynecological Oncology, Zhejiang Cancer Hospital, Hangzhou 310022, China; more

Corresponding email(s):   yangyue@zjcc.org.cn

Key Words:  Cervical cancer, Pregnancy, Treatment, Prognosis

Xiang Zhang, Yong-liang Gao, Yue Yang. Treatment and prognosis of cervical cancer associated with pregnancy: analysis of 20 cases from a Chinese tumor institution[J]. Journal of Zhejiang University Science B, 2015, 16(5): 388-394.

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DOI - 10.1631/jzus.B1400251

This study was designed to investigate the therapeutic approaches and prognosis for cervical cancer associated with pregnancy. Clinical information, therapeutic strategies, and follow-up results of 20 patients with cervical cancer associated with pregnancy from Jan. 2000 to June 2009 in the Zhejiang Cancer Hospital were retrospectively analyzed. The International Federation of Gynecology and Obstetrics (FIGO) stages were: in situ (n=1), stage IA1 (n=1), stage IB1 (n=5), stage IB2 (n=1), stage IIA (n=8), stage IIB (n=3), and stage IIIB (n=1). Eight patients were in the first trimester of pregnancy, four in the second, two in the third, and six at postpartum when diagnosed. The therapeutic strategies were either single or combined modalities, including surgery, radiotherapy, and chemotherapy. Fourteen patients survived, five patients died (four of remote metastasis and one of uremia), and one patient was lost to follow-up. One newborn from a patient at stage IIA carcinoma in the third trimester with postponed therapy six weeks after diagnosis survived. Retarded fetal growth was observed in one patient receiving neoadjuvant chemotherapy and cesarean section. Out of the six postpartum patients, three underwent cesarean section and survived, whereas only one out of the three who underwent vaginal delivery survived. The remaining two died of remote metastasis. Therefore, personalized treatment is necessary for cervical cancer associated with pregnancy. cervical cancer patients in the third trimester of pregnancy can continue the pregnancy for a short period of time. There may be potential risk for the fetus by chemotherapy during pregnancy. Cesarean section is the preferred mode of delivery for pregnant cervical cancer patients.




Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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