Full Text:   <3129>

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CLC number: 

On-line Access: 2024-08-27

Received: 2023-10-17

Revision Accepted: 2024-05-08

Crosschecked: 0000-00-00

Cited: 0

Clicked: 4404

Citations:  Bibtex RefMan EndNote GB/T7714

 ORCID:

Wenchuan WU

https://orcid.org/0000-0001-6317-3417

Ning PU

https://orcid.org/0000-0002-3123-493X

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Article info.
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Journal of Zhejiang University SCIENCE B 2021 Vol.22 No.12 P.971-984

http://doi.org/10.1631/jzus.B2100110


Basophils as a potential therapeutic target in cancer


Author(s):  Jicheng ZHANG, Hanlin YIN, Qiangda CHEN, Guochao ZHAO, Wenhui LOU, Wenchuan WU, Ning PU

Affiliation(s):  Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai 200032, China; more

Corresponding email(s):   npu15@fudan.edu.cn, wu.wenchuan@zs-hospital.sh.cn

Key Words:  Basophil, Cancer, Cytokine, Chemokine, Tumor microenvironment


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Abstract: 
basophils, which are considered as redundant relatives of mast cells and the rarest granulocytes in peripheral circulation, have been neglected by researchers in the past decades. Previous studies have revealed their vital roles in allergic diseases and parasitic infections. Intriguingly, recent studies even reported that basophils might be associated with cancer development, as activated basophils synthesize and release a variety of cytokines and chemokines in response to cancers. However, it is still subject to debate whether basophils function as tumor-protecting or tumor-promoting components; the answer may depend on the tumor biology and the microenvironment. Herein, we reviewed the role of basophils in cancers, and highlighted some potential and promising therapeutic strategies.

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