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On-line Access: 2024-08-27
Received: 2023-10-17
Revision Accepted: 2024-05-08
Crosschecked: 2024-01-02
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Bioceramic scaffolds with two-step internal/external modification of copper-containing polydopamine enhance antibacterial and alveolar bone regeneration capability
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Abstract: Magnesium-doped calcium silicate (CS) bioceramic scaffolds have unique advantages in mandibular defect repair; however, they lack antibacterial properties to cope with the complex oral microbiome. Herein, for the first time, the CS scaffold was functionally modified with a novel copper-containing polydopamine (PDA(Cu2+)) rapid deposition method, to construct internally modified (*P), externally modified (@PDA), and dually modified (*P@PDA) scaffolds. The morphology, degradation behavior, and mechanical properties of the obtained scaffolds were evaluated in vitro. The results showed that the CS*P@PDA had a unique micro-/nano-structural surface and appreciable mechanical resistance. During the prolonged immersion stage, the release of copper ions from the CS*P@PDA scaffolds was rapid in the early stage and exhibited long-term sustained release. The in vitro evaluation revealed that the release behavior of copper ions ascribed an excellent antibacterial effect to the CS*P@PDA, while the scaffolds retained good cytocompatibility with improved osteogenesis and angiogenesis effects. Finally, the PDA(Cu2+)-modified scaffolds showed effective early bone regeneration in a critical-size rabbit mandibular defect model. Overall, it was indicated that considerable antibacterial property along with the enhancement of alveolar bone regeneration can be imparted to the scaffold by the two-step PDA(Cu2+) modification, and the convenience and wide applicability of this technique make it a promising strategy to avoid bacterial infections on implants.
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Xiaojian JIANG, Lihong LEI, Weilian SUN, Yingming WEI, Jiayin HAN, Shuaiqi ZHONG, Xianyan YANG, Zhongru GOU, Lili CHEN. Bioceramic scaffolds with two-step internal/external modification of copper-containing polydopamine enhance antibacterial and alveolar bone regeneration capability[J]. Journal of Zhejiang University Science B, 2024, 25(1): 65-82.
@article{title="Bioceramic scaffolds with two-step internal/external modification of copper-containing polydopamine enhance antibacterial and alveolar bone regeneration capability",
author="Xiaojian JIANG, Lihong LEI, Weilian SUN, Yingming WEI, Jiayin HAN, Shuaiqi ZHONG, Xianyan YANG, Zhongru GOU, Lili CHEN",
journal="Journal of Zhejiang University Science B",
volume="25",
number="1",
pages="65-82",
year="2024",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.B23d0004"
}
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%T Bioceramic scaffolds with two-step internal/external modification of copper-containing polydopamine enhance antibacterial and alveolar bone regeneration capability
%A Xiaojian JIANG
%A Lihong LEI
%A Weilian SUN
%A Yingming WEI
%A Jiayin HAN
%A Shuaiqi ZHONG
%A Xianyan YANG
%A Zhongru GOU
%A Lili CHEN
%J Journal of Zhejiang University SCIENCE B
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.B23d0004
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A1 - Xiaojian JIANG
A1 - Lihong LEI
A1 - Weilian SUN
A1 - Yingming WEI
A1 - Jiayin HAN
A1 - Shuaiqi ZHONG
A1 - Xianyan YANG
A1 - Zhongru GOU
A1 - Lili CHEN
J0 - Journal of Zhejiang University Science B
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%@ 1673-1581
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.B23d0004
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