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Journal of Zhejiang University SCIENCE B 2005 Vol.6 No.4 P.265~271

http://doi.org/10.1631/jzus.2005.B0265


Inhibitory effects of jujuboside A on EEG and hippocampal glutamate in hyperactive rat


Author(s):  LU Ying-jun, ZHOU Jun, ZHANG Shao-min, ZHANG Heng-yi, ZHENG Xiao-xiang

Affiliation(s):  Department of Biomedical Engineering, Zhejiang University, Hangzhou 310027, China

Corresponding email(s):   heavenbird_l@hotmail.com, zxx@mail.hz.zj.cn

Key Words:  Jujuboside A (JuA), Diazepam, Glutamate (Glu), Electroencephalogram (EEG), Hyperactivity, Penicillin sodium (Na-PCN), Power spectral density (PSD), Gravity frequency


LU Ying-jun, ZHOU Jun, ZHANG Shao-min, ZHANG Heng-yi, ZHENG Xiao-xiang. Inhibitory effects of jujuboside A on EEG and hippocampal glutamate in hyperactive rat[J]. Journal of Zhejiang University Science B, 2005, 6(4): 265~271.

@article{title="Inhibitory effects of jujuboside A on EEG and hippocampal glutamate in hyperactive rat",
author="LU Ying-jun, ZHOU Jun, ZHANG Shao-min, ZHANG Heng-yi, ZHENG Xiao-xiang",
journal="Journal of Zhejiang University Science B",
volume="6",
number="4",
pages="265~271",
year="2005",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2005.B0265"
}

%0 Journal Article
%T Inhibitory effects of jujuboside A on EEG and hippocampal glutamate in hyperactive rat
%A LU Ying-jun
%A ZHOU Jun
%A ZHANG Shao-min
%A ZHANG Heng-yi
%A ZHENG Xiao-xiang
%J Journal of Zhejiang University SCIENCE B
%V 6
%N 4
%P 265~271
%@ 1673-1581
%D 2005
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2005.B0265

TY - JOUR
T1 - Inhibitory effects of jujuboside A on EEG and hippocampal glutamate in hyperactive rat
A1 - LU Ying-jun
A1 - ZHOU Jun
A1 - ZHANG Shao-min
A1 - ZHANG Heng-yi
A1 - ZHENG Xiao-xiang
J0 - Journal of Zhejiang University Science B
VL - 6
IS - 4
SP - 265
EP - 271
%@ 1673-1581
Y1 - 2005
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2005.B0265


Abstract: 
In this study, the inhibitory effect of jujuboside A (JuA) on a penicillin sodium (Na-PCN) induced hyperactivity model was investigated. Cortical EEG (electroencephalogram) and the concentration of hippocampal glutamate (Glu) were monitored simultaneously in vivo as indicators of rat’s excitatory state. power spectral density (PSD) and gravity frequency of PSD were calculated. JuA (0.05 g/L and 0.1 g/L) inhibited the EEG excitation effect caused by Na-PCN by increasing the power of δ1 and δ2 bands (P<0.01 vs model) and lowering the gravity frequency of PSD (P<0.01 vs model). JuA also remarkably reduced the Glu elevation induced by Na-PCN (P<0.05 vs model). diazepam also depressed Glu concentration and lowered the gravity frequency, but it showed a different EEG pattern in increased β2-activity (P<0.01 vs model). EEG excitation caused by Na-PCN correlated with Glu elevation during the first hour. Neurophysiological inhibitory effects of JuA and diazepam were more persistent than their Glu inhibitoty effects.

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Reference

[1] Begley, D.J., Reichel, A., Ermisch, A., 1994. Simple high-performance liquid chromatographic analysis of free primary amino acid concentrations in rats plasma and cisternal cerebrospinal fluid. J Chromatogr B, 657:185-191.

[2] Bradford, H.F., 1995. Glutamate, GABA and epilepsy. Prog. Neurobiol, 47:477-511.

[3] Chen, X.C., Sheng, C., Zheng, X.X., 2001. Direct nitric oxide imaging in cultured hippocampal neurons with diaminoanthraquinone and confocal microscopy. Cell Biol Int, 25:593-598.

[4] El-Yamany, N.A., Horn, E., 2002. Time courses of aspartate and glutamate concentrations in the focus area during penicillin sodium induced epileptiform activity in awake rats. Arch Ital Biol, 140:13-30.

[5] Fiacro, J., Francisco, V., Jose, C.R., Francisco, E.V., Marcos, V., Hector, P., 1999. Seizures induced by penicillin microinjections in the mesencephalic tegmentum. Epilepsy Research, 38:33-44.

[6] Futamachi, K.J., Prince, D.A., 1975. Effects of penicillin on an excitatory synapse. Brain Research, 100:589-597.

[7] Horn, E., Esseling, K., 1993. Arrest of seizure series induced by an intracortical injection of penicillin in the awake rat. Pharm Biochem Behav, 45:857-863.

[8] Horn, E., Esseling, K., Wagner, R., 1991. Time course of interictal EEG patterns induced by a penicillin injection into the olfactory cortex. Pharmacol Biochem Behav, 40:351-357.

[9] Kozhechkin, S.N., 2003. Comparative electroencephalographic evaluation of anxiolytics afobazol and diazepam in MR and MNRA inbred rats with different anxiety levels. Eksp Klin Farmakol, 66:38-41.

[10] Marijtje, L.A.J., Clementina, M.R., Jan, E., Willie, J.S., Anke, S., Anton, M.L.C., 2000. The influence of diazepam on the electroencephalogram evoked potential interrelation in rats. Neurosci Lett, 293:83-86.

[11] Ribak, C.E., 1987. Epilepsy hypothesis. Science, 238:1292-1293.

[12] Shou, C.H., Wang, J., Zheng, X.X., Guo, D.W., 2001. Inhibitory effects of Jujuboside A on penicillin sodium induced hyperactivity in rat hippocampal CA1 area in vitro. Acta Pharmacol Sin, 22:986-990.

[13] Shou, C.H., Feng, Z.Y., Wang, J., Zheng, X.X., 2002. The inhibitory effects of jujuboside A on rat hippocampus in vivo and in vitro. Planta Med, 68:799-803.

[14] Soderpalm, B., 2002. Anticonvulsants: aspects of their mechanisms of action. Eur J Pain, 6(Suppl A):3-9.

[15] Su, S., Zhang, H.Y., Zheng, X.X., 2003. Sorting the sleep stages of rat based on the gravity frequency and complexity measure. Chinese Pharamcol Bulletin, 19:949-953 (in Chinese).

[16] Ticku, M.K., 1983. Benzodiazepine-GABA receptor-ionophore complex, current concepts. Neuropharmacol, 22:1459-1470.

[17] Uysal, H., Kuli, P., Caglar, S., Inan, L.E., Akarsu, E.S., Palaoglu, O., Ayhan, I.H., 1996. Antiseizure activity of insulin: insulin inhibits pentylenetetrazole, penicillin and kainic acid-induced seizures in rats. Epilepsy Research, 25:185-190.

[18] Ye, W.L., 1988. High performance liquid chromatographic determination of amino acids in brain by precolumn derivatization with o-phthaldialdehyde. Acta Physiologica Sin, 40:308-313.

[19] Zhang, M., Ning, G.M., Shou, C.H., Lu, Y.J., Hong, D.H., Zheng, X.X., 2003. Inhibitory effect of jujuboside A on glutamate-mediated excitatory signal pathway in hippocampus. Planta Med, 69:692-695.

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