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Journal of Zhejiang University SCIENCE B 2005 Vol.6 No.11 P.1045-1056


Acute phase reaction and acute phase proteins


Affiliation(s):  Department of Pathobiology, Faculty of Veterinary Medicine, Utrecht University, Utrecht, the Netherlands; more

Corresponding email(s):   e.gruys@vet.uu.nl

Key Words:  Acute phase protein, Acute phase reaction, Animal health, Assessment, Cytokine, Index, Nutrition

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GRUYS E., TOUSSAINT M.J.M., NIEWOLD T.A., KOOPMANS S.J.. Acute phase reaction and acute phase proteins[J]. Journal of Zhejiang University Science B, 2005, 6(11): 1045-1056.

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%T Acute phase reaction and acute phase proteins
%J Journal of Zhejiang University SCIENCE B
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%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2005.B1045

T1 - Acute phase reaction and acute phase proteins
J0 - Journal of Zhejiang University Science B
VL - 6
IS - 11
SP - 1045
EP - 1056
%@ 1673-1581
Y1 - 2005
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2005.B1045

A review of the systemic acute phase reaction with major cytokines involved, and the hepatic metabolic changes, negative and positive acute phase proteins (APPs) with function and associated pathology is given. It appears that APPs represent appropriate analytes for assessment of animal health. Whereas they represent non-specific markers as biological effect reactants, they can be used for assessing nutritional deficits and reactive processes, especially when positive and negative acute phase variables are combined in an index. When such acute phase index is applied to separate healthy animals from animals with some disease, much better results are obtained than with single analytes and statistically acceptable results for culling individual animals may be reached. Unfortunately at present no cheap, comprehensive and easy to use system is available for assessing various acute phase proteins in serum or blood samples at the same time. Protein microarray or fluid phase microchip technology may satisfy this need; and permit simultaneous analysis of numerous analytes in the same small volume sample and enable integration of information derived from systemic reactivity and nutrition with disease specific variables. Applying such technology may help to solve health problems in various countries not only in animal husbandry but also in human populations.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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Open peer comments: Debate/Discuss/Question/Opinion



2014-09-01 18:42:54

for my phd thesis


2014-04-09 03:21:27

I need to know more about this subject.

gehad@No address<gehad.donia@yahoo.com>

2013-02-21 16:44:45

iam interesting by this subject


2011-05-04 03:23:18

Useful paper


2010-12-24 18:31:14



2010-12-24 16:20:38

Useful article

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