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Journal of Zhejiang University SCIENCE B 2006 Vol.7 No.12 P.947~956

http://doi.org/10.1631/jzus.2006.B0947


Activity optimization method in SPECT: A comparison with ROC analysis


Author(s):  DÍ,AZ Marlé,n Pé,rez, RIZO Oscar Dí,az, DÍ,AZ Adlin Ló,pez, APARICIO Eric Esté,vez, DÍ,AZ Reinaldo Roque

Affiliation(s):  Center for Studies on Electronics & Info Tech. Images Group, Central University of Las Villas, Santa Clara 54830, Cuba; more

Corresponding email(s):   mperez@uclv.edu.cu

Key Words:  Activity optimization, Image quality, SPECT, Discriminant analysis, ROC curves


DÍAZ Marlén Pérez, RIZO Oscar Díaz, DÍAZ Adlin López, APARICIO Eric Estévez, DÍAZ Reinaldo Roque. Activity optimization method in SPECT: A comparison with ROC analysis[J]. Journal of Zhejiang University Science B, 2006, 7(12): 947~956.

@article{title="Activity optimization method in SPECT: A comparison with ROC analysis",
author="DÍAZ Marlén Pérez, RIZO Oscar Díaz, DÍAZ Adlin López, APARICIO Eric Estévez, DÍAZ Reinaldo Roque",
journal="Journal of Zhejiang University Science B",
volume="7",
number="12",
pages="947~956",
year="2006",
publisher="Zhejiang University Press & Springer",
doi="10.1631/jzus.2006.B0947"
}

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%A AZ Adlin Ló
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T1 - Activity optimization method in SPECT: A comparison with ROC analysis
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A1 - RIZO Oscar Dí
A1 - az
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A1 - AZ Adlin Ló
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A1 - APARICIO Eric Esté
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A1 - AZ Reinaldo Roque
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SP - 947
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PB - Zhejiang University Press & Springer
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DOI - 10.1631/jzus.2006.B0947


Abstract: 
A discriminant method for optimizing activity in nuclear medicine studies is validated by comparison with ROC (received operating characteristic)-curves. The method is tested in 21 single photon emission computerized tomography (SPECT), performed with a cardiac phantom. Three different lesions (L1, L2 and L3) were placed in the myocardium-wall by pairs for each SPECT. Three activities (84, 37 or 18.5 MBq) of 99mTc were used as background. Linear discriminant analysis was used to select the parameters that characterize image quality among the measured variables in the images [(Background-to-Lesion (B/Li) and Signal-to-Noise (Si/N) ratios)]. Two clusters with different image quality (P=0.021) were obtained. The ratios B/L1, B/L2 and B/L3 are the parameters used to construct the function with 100% of cases correctly classified into the clusters. The value of 37 MBq was the lowest tested activity for which good results for the B/Li ratios were obtained. The result coincides with the applied ROC-analysis (r=0.89).

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article

Reference

[1] Evans, A., 1981. The Evaluation of Medical Images. In: Adams Hilger Ltd. (Ed.), Image Evaluation by Signal Detection Theory. Medical Physics Handbook. Techno House, UK, p.80-113.

[2] Goodenough, J., 1981. Technical Aspects of CT. In: Newton 8 Potts (Ed.), Psychophysical Perception of Computed Tomography Images. Washington DC, p.3993-4021.

[3] Greer, L., Scarfone, C., 1999. Data Spectrum’s SPECT User’s Manual. Data Spectrum Corporation 437 Dimmock Mill Road Hillsboroug, NC 27278.

[4] Hanley, J., McNeil, B., 1982. The meaning and use of the area under a receiver operating characteristic (ROC) curve. Radiology, 143(1):29-36.

[5] ICRP (International Commission on Radiological Protection) 52, 1987. Protection of the Patient in Nuclear Medicine. Publication 52 Ann., ICRP 17(4). Pergamon Press, Oxford.

[6] ICRP (International Commission on Radiological Protection) 53, 1987. Radiation Dose to Patients from radiopharmaceutical. Publication 53 Ann., ICRP 18(1-4). Pergamon Press, Oxford.

[7] ICRP (International Commission on Radiological Protection) 60, 1991. Recommendations of the International Commission on Radiological Protection. Publication 60 Ann., ICRP 21(1-3). Pergamon Press, Oxford.

[8] Juez, P., Díaz, F.,1996. Probabilities and Statistic in Medicine Applications in the Clinic Practice and Sanitary. Madrid, p.189-222.

[9] Mattsson, S., Jacobsson, L., Vestergren, E., 1998. The basic principles in assessment and selection of reference doses: considerations in nuclear medicine. Rad. Prot. Dosim., 80(1):23-27.

[10] Metz, C., 1978. Basic principles of ROC-analysis. Sem. Nucl. Med., 8(1):283-298.

[11] Moonen, M., Jacobsson, L., 1997. Effect of administered activity on precision in the assessment of renal function using gamma camera renography. Nucl. Med. Commun., 18(4):346-351.

[12] NEMA (National Electrical Manufacturers Association), 1994. Performance Measurements of Scintillation Cameras. Washington DC.

[13] Perez, M., Quevedo, J., Ponce, F., Diaz-Rizo, O., 2002a. Administered activity optimisation in patients studied by equilibrium gated radionuclide ventriculography using pyrophosphate and Tc-99m. Nucl. Med. Commun., 23(3):347-353.

[14] Perez, M., Quevedo, J., Diaz-Rizo, O., Dopico, R., Estévez, A., Viamonte, A., 2002b. Administered activity optimization in skeletal scanning using MDP labelled 99m-Tc. ALASBIMN J., 16(4):AJ16-5.

[15] Perez, M., Diaz-Rizo, O., Dopico, R., Estéves, E., 2002c. Administered activity optimization in renal scintigraphy with DMSA-99mTc. ALASBIMN J., 28(5):AJ20-5.

[16] Perez, M., Estévez, E., Diaz-Rizo, O., Roque, R., Hernández, C., 2003. Administered activity optimization in 99mTc-MAG3 renography for adults. J. Nucl. Med. Technol., 31(1):216-221.

[17] Phelps, M., Hoffman, E., Mullani, N., Ter-Pogossian, M., 1975. Application of annihilation coincidence detection to transaxial reconstruction tomography. J. Nucl. Med., 16(2):210-224.

[18] Stark, S., Carlsson, S., 1997. Digital filtering of bone scans: a ROC study. Nucl. Med. Commun., 18(2):98-104.

[19] Tsui, B., Zhao, X., 1994. Quantitative single-photon computed tomography: basics and clinical considerations. Sem. Nucl. Med., 24(1):38-65.

[20] Venables, W., Ripley, B., 1994. Statistics and Computing. Modern Applied Statistics with S-Plus. Springer-Verlag, New York, p.311-318.

[21] Vestergren, E., Jacobsson, L., Bjure, J., Mattsson, S., 1996. Radiopharmaceutical dosage of 99mTc-HMPAO for cerebral blood flow SPECT studies in children. Nucl. Med. Commun., 17(4):423-429.

[22] Vestergren, E., Jacobsson, L., Lind, A., Sixt, R., Mattson, S., 1998. Administered activity of Tc-99m-DMSA for kidney scintigraphy in children. Nucl. Med. Commun., 19(6):695-701.

[23] Vestergren, E., Jacobsson, L., Moonen, M., Eklind, I., Sixt, R., Mattsson, S., 1999. Administered activity of 99mTc-MAG-3 for gamma camera renography in children. Nucl. Med. Commun., 20(8):799-806.

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