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Received: 2007-01-19

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Journal of Zhejiang University SCIENCE B 2007 Vol.8 No.4 P.221~227


Proteomic analysis of the serum in patients with idiopathic pulmonary arterial hypertension

Author(s):  YU Min, WANG Xing-xiang, ZHANG Fu-rong, SHANG Yun-peng, DU Yu-xi, CHEN Hong-juan, CHEN Jun-zhu

Affiliation(s):  Department of Cardiovascular Disease, the First Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310003, China; more

Corresponding email(s):   wangxx0571@yahoo.com.cn, chenjunzhu01@163.com

Key Words:  Idiopathic pulmonary arterial hypertension, Two-dimensional gel electrophoresis, LC-MS/MS

YU Min, WANG Xing-xiang, ZHANG Fu-rong, SHANG Yun-peng, DU Yu-xi, CHEN Hong-juan, CHEN Jun-zhu. Proteomic analysis of the serum in patients with idiopathic pulmonary arterial hypertension[J]. Journal of Zhejiang University Science B, 2007, 8(4): 221~227.

@article{title="Proteomic analysis of the serum in patients with idiopathic pulmonary arterial hypertension",
author="YU Min, WANG Xing-xiang, ZHANG Fu-rong, SHANG Yun-peng, DU Yu-xi, CHEN Hong-juan, CHEN Jun-zhu",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Proteomic analysis of the serum in patients with idiopathic pulmonary arterial hypertension
%A YU Min
%A WANG Xing-xiang
%A ZHANG Fu-rong
%A SHANG Yun-peng
%A DU Yu-xi
%A CHEN Hong-juan
%A CHEN Jun-zhu
%J Journal of Zhejiang University SCIENCE B
%V 8
%N 4
%P 221~227
%@ 1673-1581
%D 2007
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2007.B0221

T1 - Proteomic analysis of the serum in patients with idiopathic pulmonary arterial hypertension
A1 - YU Min
A1 - WANG Xing-xiang
A1 - ZHANG Fu-rong
A1 - SHANG Yun-peng
A1 - DU Yu-xi
A1 - CHEN Hong-juan
A1 - CHEN Jun-zhu
J0 - Journal of Zhejiang University Science B
VL - 8
IS - 4
SP - 221
EP - 227
%@ 1673-1581
Y1 - 2007
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2007.B0221

idiopathic pulmonary arterial hypertension (IPAH) is a rare disease of unknown etiology. The exact pathogenesis of pulmonary arterial hypertension is still not well known. In the past decades, many protein molecules have been found to be involved in the development of IPAH. With proteomic techniques, profiling of human plasma proteome becomes more feasible in searching for disease-related markers. In present study, we showed the protein expression profiles of the serum of IPAH and healthy controls after depleting a few high-abundant proteins in serum. Thirteen spots had changed significantly in IPAH compared with healthy controls and were identified by LC-MS/MS. Alpha-1-antitrypsin and vitronectin were down-regulated in IPAH and may be valuable candidates for further explorations of their roles in the development of IPAH.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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