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Journal of Zhejiang University SCIENCE B 2007 Vol.8 No.4 P.228~236


Study progress on mechanism of severe acute pancreatitis complicated with hepatic injury

Author(s):  ZHANG Xi-ping, WANG Lei, ZHANG Jie

Affiliation(s):  Department of General Surgery, Hangzhou First People’ more

Corresponding email(s):   zxp99688@vip.163.com

Key Words:  Severe acute pancreatitis, Hepatic injury, Inflammatory mediators, Cytokines, Endotoxin, Nuclear factor-&kappa, B

ZHANG Xi-ping, WANG Lei, ZHANG Jie. Study progress on mechanism of severe acute pancreatitis complicated with hepatic injury[J]. Journal of Zhejiang University Science B, 2007, 8(4): 228~236.

@article{title="Study progress on mechanism of severe acute pancreatitis complicated with hepatic injury",
author="ZHANG Xi-ping, WANG Lei, ZHANG Jie",
journal="Journal of Zhejiang University Science B",
publisher="Zhejiang University Press & Springer",

%0 Journal Article
%T Study progress on mechanism of severe acute pancreatitis complicated with hepatic injury
%A ZHANG Xi-ping
%J Journal of Zhejiang University SCIENCE B
%V 8
%N 4
%P 228~236
%@ 1673-1581
%D 2007
%I Zhejiang University Press & Springer
%DOI 10.1631/jzus.2007.B0228

T1 - Study progress on mechanism of severe acute pancreatitis complicated with hepatic injury
A1 - ZHANG Xi-ping
A1 - WANG Lei
A1 - ZHANG Jie
J0 - Journal of Zhejiang University Science B
VL - 8
IS - 4
SP - 228
EP - 236
%@ 1673-1581
Y1 - 2007
PB - Zhejiang University Press & Springer
ER -
DOI - 10.1631/jzus.2007.B0228

Study on the action mechanism of b%5D=abstract&ck%5b%5D=keyword'>b>inflammatory mediators generated by the b%5D=abstract&ck%5b%5D=keyword'>b>severe acute pancreatitis (SAP) in multiple organ injury is a hotspot in the surgical field. In clinical practice, the main complicated organ dysfunctions are shock, respiratory failure, renal failure, encephalopathy, with the rate of hepatic diseases being closely next to them. The b%5D=abstract&ck%5b%5D=keyword'>b>hepatic injury caused by SAP cannot only aggravate the state of pancreatitis, but also develop into hepatic failure and cause patient death. Its complicated pathogenic mechanism is an obstacle in clinical treatment. Among many pathogenic factors, the changes of vasoactive substances, participation of b%5D=abstract&ck%5b%5D=keyword'>b>inflammatory mediators as well as OFR (oxygen free radical), b%5D=abstract&ck%5b%5D=keyword'>b>endotoxin, etc. may play important roles in its progression.

Darkslateblue:Affiliate; Royal Blue:Author; Turquoise:Article


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